Effective connectivity reveals right-hemisphere dominance in audiospatial perception: implications for models of spatial neglect

Dietz, Martin J., Friston, Karl J., Mattingley, Jason B., Roepstorff, Andreas and Garrido, Marta I. (2014) Effective connectivity reveals right-hemisphere dominance in audiospatial perception: implications for models of spatial neglect. Journal of Neuroscience, 34 14: 5003-5011. doi:10.1523/JNEUROSCI.3765-13.2014

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Author Dietz, Martin J.
Friston, Karl J.
Mattingley, Jason B.
Roepstorff, Andreas
Garrido, Marta I.
Title Effective connectivity reveals right-hemisphere dominance in audiospatial perception: implications for models of spatial neglect
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 1529-2401
0270-6474
Publication date 2014-04-02
Year available 2014
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.3765-13.2014
Open Access Status File (Publisher version)
Volume 34
Issue 14
Start page 5003
End page 5011
Total pages 9
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Abstract Detecting the location of salient sounds in the environment rests on the brain's ability to use differences in sounds arriving at both ears. Functional neuroimaging studies in humans indicate that the left and right auditory hemispaces are coded asymmetrically, with a rightward attentional bias that reflects spatial attention in vision. Neuropsychological observations in patients with spatial neglect have led to the formulation of two competing models: the orientation bias and right-hemisphere dominance models. The orientation bias model posits a symmetrical mapping between one side of the sensorium and the contralateral hemisphere, with mutual inhibition of the ipsilateral hemisphere. The right-hemisphere dominance model introduces a functional asymmetry in the brain's coding of space: the left hemisphere represents the right side, whereas the right hemisphere represents both sides of the sensorium. We used Dynamic Causal Modeling of effective connectivity and Bayesian model comparison to adjudicate between these alternative network architectures, based on human electroencephalographic data acquired during an auditory location oddball paradigm. Our results support a hemispheric asymmetry in a frontoparietal network that conforms to the right-hemisphere dominance model.Weshow that, within this frontoparietal network, forward connectivity increases selectively in the hemisphere contralateral to the side of sensory stimulation. We interpret this finding in light of hierarchical predictive coding as a selective increase in attentional gain, which is mediated by feedforward connections that carry precision-weighted prediction errors during perceptual inference. This finding supports the disconnection hypothesis of unilateral neglect and has implications for theories of its etiology.
Keyword Audiospatial
Bayesian
Connectivity
DCM
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 088130
091593
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Psychology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 23 times in Scopus Article | Citations
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