Treatment of oral fungal infections using antimicrobial photodynamic therapy: a systematic review of currently available evidence

Javed, Fawad, Samaranayake, Lakshman P. and Romanos, Georgios E. (2014) Treatment of oral fungal infections using antimicrobial photodynamic therapy: a systematic review of currently available evidence. Photochemical and Photobiological Sciences, 13 5: 726-734. doi:10.1039/c3pp50426c


Author Javed, Fawad
Samaranayake, Lakshman P.
Romanos, Georgios E.
Title Treatment of oral fungal infections using antimicrobial photodynamic therapy: a systematic review of currently available evidence
Journal name Photochemical and Photobiological Sciences   Check publisher's open access policy
ISSN 1474-9092
1474-905X
Publication date 2014-05-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/c3pp50426c
Open Access Status Not Open Access
Volume 13
Issue 5
Start page 726
End page 734
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2015
Language eng
Formatted abstract
The aim was to review the efficacy of antimicrobial photodynamic therapy (PDT) in the treatment of oral fungal infections. To address the focused question “Should PDT be considered a possible treatment regimen for oral fungal infections?” PubMed/Medline and Google-Scholar databases were searched from 1997 up to March 2014 using various combinations of the following key words: “Candida albicans”; “Candidiasis”; “Candidosis”; “denture stomatitis”; “oral” and “photodynamic therapy”. Original studies, experimental studies and articles published solely in English language were sought. Letters to the editor, historic reviews and unpublished data were excluded. Pattern of the present literature review was customized to mainly summarize the pertinent information. Fifteen studies (3 clinical and 12 experimental) were included. All studies reported antimicrobial PDT to be an effective antifungal treatment strategy. One study reported PDT and azole therapy to be equally effective in the treatment of oral fungal infections. Methylene blue, toluidine blue and porphyrin derivative were the most commonly used photosensitizers. The laser wavelengths and power output ranged between [similar]455 nm–660 nm and 30 mW–400 mW. The energy fluence ranged between 26–245 J cm−2 and the duration or irradiation ranged between 10 seconds and 26 minutes. Clinical effectiveness of antimicrobial PDT as a potent therapeutic strategy for oral fungal infections requires further investigations.
Keyword Oral fungal infections
Photodynamic therapy
Candida albicans
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Dentistry Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 06 May 2014, 12:12:46 EST by System User on behalf of School of Dentistry