Nanocomposite-strengthened dissolving microneedles for improved transdermal delivery to human skin

Yan, Li, Raphael, Anthony P., Zhu, Xiaoyue, Wang, Beilei, Chen, Wei, Tang, Tao, Deng, Yan, Sant, Himanshu J., Zhu, Guangyu, Choy, Kwong Wai, Gale, Bruce K., Prow, Tarl W. and Chen, Xianfeng (2014) Nanocomposite-strengthened dissolving microneedles for improved transdermal delivery to human skin. Advanced Healthcare Materials, 3 4: 555-564. doi:10.1002/adhm.201300312

Author Yan, Li
Raphael, Anthony P.
Zhu, Xiaoyue
Wang, Beilei
Chen, Wei
Tang, Tao
Deng, Yan
Sant, Himanshu J.
Zhu, Guangyu
Choy, Kwong Wai
Gale, Bruce K.
Prow, Tarl W.
Chen, Xianfeng
Title Nanocomposite-strengthened dissolving microneedles for improved transdermal delivery to human skin
Journal name Advanced Healthcare Materials   Check publisher's open access policy
ISSN 2192-2659
Publication date 2014-04-01
Year available 2013
Sub-type Article (original research)
DOI 10.1002/adhm.201300312
Open Access Status Not yet assessed
Volume 3
Issue 4
Start page 555
End page 564
Total pages 10
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Subject 2502 Biomaterials
2204 Biomedical Engineering
3003 Pharmaceutical Science
Abstract Delivery of drugs and biomolecules into skin has significant advantages. To achieve this, herein, a nanomaterial-strengthened dissolving microneedle patch for transdermal delivery is reported. The patch comprises thousands of microneedles, which are composed of dissolving polymers, nanomaterials, and drug/biomolecules in their interior. With the addition of nanomaterials, the mechanical property of generally weak dissolving polymers can be dramatically improved without sacrificing dissolution rate within skin. In this experiments, layered double hydroxides (LDH) nanoparticles are incorporated into sodium carboxymethylcellulose (CMC) to form a nanocomposite. The results show that, by adding 5 wt% of LDH nanoparticles into CMC, the mechanical strength significantly increased. Small and densely packed CMC-LDH microneedles penetrate human and pig skin more reliably than pure CMC ones and attractively the nanocomposite-strengthened microneedles dissolve in skin and release payload within only 1 min. Finally, the application of using the nanocomposite-strengthened microneedle arrays is tested for in vivo vaccine delivery and the results show that significantly stronger antibody response could be induced when compared with subcutaneous injection. These data suggest that nanomaterials could be useful for fabricating densely packed and small polymer microneedles that have robust mechanical properties and rapid dissolution rates and therefore potential use in clinical applications.
Keyword Biomedical applications
Polymeric material
Transdermal delivery
Vaccine delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 7200247
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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