Treatment with a nonsteroidal antiinflammatory drug after calving did not improve milk production, health, or reproduction parameters in pasture-grazed dairy cows

Meier, S., Priest, N. V., Burke, C. R., Kay, J. K., McDougall, S., Mitchell, M. D., Walker, C. G., Heiser, A., Loor, J. J. and Roche, J. R. (2014) Treatment with a nonsteroidal antiinflammatory drug after calving did not improve milk production, health, or reproduction parameters in pasture-grazed dairy cows. Journal of Dairy Science, 97 5: 2932-2943. doi:10.3168/jds.2013-7838


Author Meier, S.
Priest, N. V.
Burke, C. R.
Kay, J. K.
McDougall, S.
Mitchell, M. D.
Walker, C. G.
Heiser, A.
Loor, J. J.
Roche, J. R.
Title Treatment with a nonsteroidal antiinflammatory drug after calving did not improve milk production, health, or reproduction parameters in pasture-grazed dairy cows
Journal name Journal of Dairy Science   Check publisher's open access policy
ISSN 1525-3198
0022-0302
Publication date 2014-05-01
Year available 2014
Sub-type Article (original research)
DOI 10.3168/jds.2013-7838
Open Access Status Not Open Access
Volume 97
Issue 5
Start page 2932
End page 2943
Total pages 12
Place of publication New York, NY, United States
Publisher Elsevier
Language eng
Abstract Previous research results have indicated an increase in pregnancy rate in pasture-grazed cows treated with a nonsteroidal antiinflammatory drug (NSAID) 3 to 4. wk postcalving, when a high proportion of nucleated cells from within the uterus were polymorphonucleated; however, no effect on milk production was detected. It was hypothesized that this lack of effect on milk production was because the administration of the NSAID was too late after calving. The aims of the current study were to evaluate the timing of administering a propionic acid-derived NSAID (i.e., carprofen) on milk production, metabolic status, uterine health, and reproductive performance. Six-hundred and thirty-nine cows (134 primiparous and 505 multiparous) calving between July 4 and September 5, 2012, in 2 herds (herd 1: n. = 228; herd 2: n. = 411) were enrolled. Using a randomized block design, cows were allocated to 1 of 3 treatment groups as they calved: (1) no treatment (control; n. = 221), (2) NSAID administered on d 1, 3, and 5 postcalving (early; n. = 214), and (3) NSAID administered on d 19, 21, and 23 postcalving (late; n. = 204). Milk production and composition, and body condition were determined weekly. Blood was sampled at 4 time points (1 precalving and 3 postcalving) to determine the effects of treatment on indicators of metabolic health and energy status. Uterine health was determined by measuring the proportion of nucleated cells that were polymorphonucleated following cytobrush sampling of the uterus between d 13 to 24 and d 30 to 49 postcalving. Irrespective of timing of application, NSAID did not affect milk production, body weight, or body condition during early lactation. Treatment with an NSAID 19 to 23. d postcalving increased the proportion of cows submitted for breeding during the first 3. wk of the seasonal breeding program (control: 85%, early: 83%, and late: 92%), but did not affect conception or pregnancy rates. No detectable effect of treatment on uterine health or circulating metabolites and minerals existed, although cows in the early NSAID treatment group had marginally lower serum β-hydroxybutyrate concentrations (0.1. mmol/L) than the other groups between 2 and 26. d in milk. In conclusion, administration of this particular NSAID at either 1 or 3. wk after calving did not improve milk production, indicators of health, or reproductive performance.
Keyword Transition cow
Nonsteroidal antiinflammatory drug
Reproduction
Health
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
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