Recent progress in adjuvant discovery for peptide-based subunit vaccines

Azmi, Fazren, Fuaad, Abdullah Al Hadi Ahmad, Skwarczynski, Mariusz and Toth, Istvan (2014) Recent progress in adjuvant discovery for peptide-based subunit vaccines. Human Vaccines and Immunotherapeutics, 10 3: 778-796. doi:10.4161/hv.27332

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Author Azmi, Fazren
Fuaad, Abdullah Al Hadi Ahmad
Skwarczynski, Mariusz
Toth, Istvan
Title Recent progress in adjuvant discovery for peptide-based subunit vaccines
Journal name Human Vaccines and Immunotherapeutics   Check publisher's open access policy
ISSN 2164-554X
2164-5515
Publication date 2014-03-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4161/hv.27332
Open Access Status DOI
Volume 10
Issue 3
Start page 778
End page 796
Total pages 19
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Language eng
Abstract Peptide-based subunit vaccines are of great interest in modern immunotherapy as they are safe, easy to produce and well defined. However, peptide antigens produce a relatively weak immune response, and thus require the use of immunostimulants (adjuvants) for optimal efficacy. Developing a safe and effective adjuvant remains a challenge for peptide-based vaccine design. Recent advances in immunology have allowed researchers to have a better understanding of the immunological implication of related diseases, which facilitates more rational design of adjuvant systems. Understanding the molecular structure of the adjuvants allows the establishment of their structure-activity relationships which is useful for the development of next-generation adjuvants. This review summarizes the current state of adjuvants development in the field of synthetic peptide-based vaccines. The structural, chemical and biological properties of adjuvants associated with their immunomodulatory effects are discussed.
Keyword Adjuvant
Dendritic cell
Peptide vaccine
Toll-like receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 3 December 2013

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
 
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