Quality-of-life aspects of primary aldosteronism

Stowasser, Michael and Ahmed, Ashraf (2014). Quality-of-life aspects of primary aldosteronism. In Per Hellman (Ed.), Primary Aldosteronism: Molecular Genetics, Endocrinology and Translational Medicine. (pp. 197-207) New York, NY, USA: Springer. doi:10.1007/978-1-4939-0509-6_13

Author Stowasser, Michael
Ahmed, Ashraf
Title of chapter Quality-of-life aspects of primary aldosteronism
Title of book Primary Aldosteronism: Molecular Genetics, Endocrinology and Translational Medicine.
Place of Publication New York, NY, USA
Publisher Springer
Publication Year 2014
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-4939-0509-6_13
ISBN 9781493905089
Editor Per Hellman
Chapter number 13
Start page 197
End page 207
Total pages 11
Total chapters 15
Language eng
Formatted Abstract/Summary
Evidence from case reports and group data suggest that primary aldosteronism (PA) is associated with a variety of mood disorders (including anxiety, irritability, and, to a lesser extent, depression) which contribute to reduced quality of life (QOL). Specific treatment (unilateral adrenalectomy for unilateral PA or aldosterone antagonist medications for bilateral PA) results in reversal of these adverse states, with benefits appearing to be more rapidly achieved and more complete with surgical versus medical therapy. Possible contributors to reduced QOL in PA include effects of hypertension, hypokalemia, medications, aldosterone-induced obstructive sleep apnea, and direct actions of aldosterone on the central nervous system (CNS), but how such putative direct central actions may come about remains speculative. As QOL is of paramount importance from the patient’s perspective, these observations add to the weight of arguments supporting early detection of PA among hypertensive populations, careful differentiation of its subtypes, and institution of appropriate specific treatment.
Keyword Primary aldosteronism
Quality of life
Mood disorders
Effects of medical treatment
Effects of surgical treatment
Central effects
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Tue, 06 May 2014, 00:31:12 EST by Ashraf Ahmed on behalf of Medicine - Princess Alexandra Hospital