Ex vivo antimalarial activity of proguanil combined with dapsone against cycloguanil-resistant plasmodium falciparum isolates

Edstein M.D., Yeo A.E.T., Shanks G.D. and Rieckmann K.H. (1997) Ex vivo antimalarial activity of proguanil combined with dapsone against cycloguanil-resistant plasmodium falciparum isolates. Acta Tropica, 66 3: 127-135. doi:10.1016/S0001-706X(97)00044-2


Author Edstein M.D.
Yeo A.E.T.
Shanks G.D.
Rieckmann K.H.
Title Ex vivo antimalarial activity of proguanil combined with dapsone against cycloguanil-resistant plasmodium falciparum isolates
Journal name Acta Tropica   Check publisher's open access policy
ISSN 0001-706X
Publication date 1997-09-10
Year available 1997
Sub-type Article (original research)
DOI 10.1016/S0001-706X(97)00044-2
Open Access Status Not yet assessed
Volume 66
Issue 3
Start page 127
End page 135
Total pages 9
Place of publication AMSTERDAM
Publisher ELSEVIER SCIENCE BV
Language eng
Subject 2405 Parasitology
2725 Infectious Diseases
Abstract The ex vivo antimalarial activity of plasma samples obtained from 20 healthy Caucasian volunteers following daily proguanil (200 mg) plus dapsone (8 mg) for malaria chemoprophylaxis inhibited five cycloguanil-resistant Thai isolates of Plasmodium falciparum. All volunteers were phenotyped as extensive metabolisers (EMs) of proguanil. Three of the five isolates were obtained from Thai soldiers who had failed malaria prophylaxis on daily proguanil (200 mg) plus dapsone (4.0 or 12.5 mg). The Thai soldiers were also classified as EMs, but had relatively lower plasma cycloguanil concentrations compared to values reported in the literature for Caucasians and black Kenyans. Although the high level of parasite resistance to cycloguanil was the most likely explanation for the Thai soldiers failing prophylaxis on proguanil plus dapsone, their low cycloguanil concentrations may have also contributed to their lack of protection. However, in areas where parasites are more susceptible to cycloguanil, such as in certain regions of Africa, proguanil plus dapsone may still be an effective chemoprophylactic drug combination. (C) 1997 Elsevier Science B.V.
Keyword Cycloguanil
Dapsone
Drug resistance
In vitro activity
Plasmodium falsiparum
Proguanil
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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