Deaths from bacterial pneumonia during 1918-19 influenza pandemic

Brundage, John F. B and Shanks, G. Dennis (2008) Deaths from bacterial pneumonia during 1918-19 influenza pandemic. Emerging Infectious Diseases, 14 8: 1193-1199. doi:10.3201/eid1408.071313

Author Brundage, John F. B
Shanks, G. Dennis
Title Deaths from bacterial pneumonia during 1918-19 influenza pandemic
Journal name Emerging Infectious Diseases   Check publisher's open access policy
ISSN 1080-6040
Publication date 2008-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3201/eid1408.071313
Open Access Status DOI
Volume 14
Issue 8
Start page 1193
End page 1199
Total pages 7
Place of publication Atlanta, GA, United States
Publisher U.S. Department of Health and Human Services * Centers for Disease Control and Prevention
Language eng
Subject 2726 Microbiology (medical)
Abstract Deaths during the 1918-19 influenza pandemic have been attributed to a hypervirulent influenza strain. Hence, preparations for the next pandemic focus almost exclusively on vaccine prevention and antiviral treatment for infections with a novel influenza strain. However, we hypothesize that infections with the pandemic strain generally caused self-limited (rarely fatal) illnesses that enabled colonizing strains of bacteria to produce highly lethal pneumonias. This sequential-infection hypothesis is consistent with characteristics of the 1918-19 pandemic, contemporaneous expert opinion, and current knowledge regarding the pathophysiologic effects of influenza viruses and their interactions with respiratory bacteria. This hypothesis suggests opportunities for prevention and treatment during the next pandemic (e.g., with bacterial vaccines and antimicrobial drugs), particularly if a pandemic strain-specific vaccine is unavailable or inaccessible to isolated, crowded, or medically underserved populations.
Keyword Immunology
Infectious Diseases
Infectious Diseases
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 186 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 05 May 2014, 21:13:59 EST by Ms Kate Rowe on behalf of School of Public Health