Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam

Thanh, Nguyen Xuan, Trung, Trieu Nguyen, Phong, Nguyen Chinh, Thien, Nguyen Xuan, Dai, Bui, Shanks, G. Dennis, Chavchich, Marina and Edstein, Michael D. (2009) Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam. Tropical Medicine and International Health, 14 5: 504-511. doi:10.1111/j.1365-3156.2009.02269.x


Author Thanh, Nguyen Xuan
Trung, Trieu Nguyen
Phong, Nguyen Chinh
Thien, Nguyen Xuan
Dai, Bui
Shanks, G. Dennis
Chavchich, Marina
Edstein, Michael D.
Title Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam
Formatted title
Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam 
Journal name Tropical Medicine and International Health   Check publisher's open access policy
ISSN 1360-2276
1365-3156
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.1111/j.1365-3156.2009.02269.x
Open Access Status Not Open Access
Volume 14
Issue 5
Start page 504
End page 511
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Objective: Artesunate-amodiaquine (AAQ) is efficacious for the treatment of uncomplicated Plasmodium falciparum malaria in Africa, but little is known about its efficacy in Southeast Asia. We compared the efficacy of dihydroartemisinin-piperaquine (DHP) and AAQ against falciparum malaria in central Vietnam.

Methods: Open, randomized clinical trial of 116 patients (36 children aged 6-14 years, 80 adults aged 15-60 years) were randomly allocated a 3-day course of either DHP (∼2.3 mg/kg dihydroartemisinin plus ∼18.5 mg/kg of piperaquine per day) or AAQ (∼4.4 mg/kg of artesunate plus ∼10.6 mg/kg of amodiaquine per day). The follow-up period was 42 days.

Results: The two drug combinations were well tolerated by all age groups with no obvious drug associated adverse events. Of the patients who completed 42 days of follow-up, 49 were on DHP (15 children, 34 adults) and 49 were on AAQ (14 children, 35 adults). The 42 day cure rates adjusted for reinfection identified by PCR genotyping for the two groups were similar [100% (49/49) and 98% (48/49) for DHP and AAQ, respectively]. With fewer reinfections, DHP appears to possess greater post-treatment prophylactic activity than AAQ.

Conclusion: AAQ, an inexpensive artemisinin-based combination, could be an additional option to DHP for the treatment of multidrug-resistant falciparum malaria in Vietnam. 
Keyword Amodiaquine
Artesunate
Dihydroartemisinin
Malaria
Piperaquine
Plasmodium falciparum
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Mon, 05 May 2014, 21:11:27 EST by Ms Kate Rowe on behalf of School of Public Health