An outbreak of Plasmodium falciparum malaria in U.S. marines deployed to Liberia

Whitman, Timothy J., Coyne, Philip E., Magill, Alan J., Blazes, David L., Green, Michael D., Milhous, Wilbur K., Burgess, Timothy H., Freilich, Daniel, Tasker, Sybil A., Azar, Ramzy G., Endy, Timothy P., Clagett, Christopher D., Deye, Gregory A., Shanks, G. Dennis and Martin, Gregory J. (2010) An outbreak of Plasmodium falciparum malaria in U.S. marines deployed to Liberia. American Journal of Tropical Medicine and Hygiene, 83 2: 258-265. doi:10.4269/ajtmh.2010.09-0774


Author Whitman, Timothy J.
Coyne, Philip E.
Magill, Alan J.
Blazes, David L.
Green, Michael D.
Milhous, Wilbur K.
Burgess, Timothy H.
Freilich, Daniel
Tasker, Sybil A.
Azar, Ramzy G.
Endy, Timothy P.
Clagett, Christopher D.
Deye, Gregory A.
Shanks, G. Dennis
Martin, Gregory J.
Title An outbreak of Plasmodium falciparum malaria in U.S. marines deployed to Liberia
Formatted title
An outbreak of Plasmodium falciparum malaria in U.S. marines deployed to Liberia 
Journal name American Journal of Tropical Medicine and Hygiene   Check publisher's open access policy
ISSN 0002-9637
1476-1645
Publication date 2010-01-01
Sub-type Article (original research)
DOI 10.4269/ajtmh.2010.09-0774
Open Access Status Not Open Access
Volume 83
Issue 2
Start page 258
End page 265
Total pages 8
Place of publication Deerfield, IL, United States
Publisher American Society of Tropical Medicine and Hygiene
Abstract In 2003, 44 U.S. Marines were evacuated from Liberia with either confirmed or presumed Plasmodium falciparum malaria. An outbreak investigation showed that only 19 (45%) used insect repellent, 5 (12%) used permethrin-treated clothing, and none used bed netting. Adherence with weekly mefloquine (MQ) was reported by 23 (55%). However, only 4 (10%) had serum MQ levels high enough to correlate with protection (> 794 ng/mL), and 9 (22%) had evidence of steady-state kinetics (MQ carboxy metabolite/MQ > 3.79). Tablets collected from Marines met USP identity and dissolution specifications for MQ. Testing failed to identify P. falciparum isolates with MQ resistance. This outbreak resulted from under use of personal protective measures and inadequate adherence with chemophrophylaxis. It is essential that all international travelers make malaria prevention measures a priority, especially when embarking to regions of the world with high transmission intensity such as west Africa. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Mon, 05 May 2014, 20:56:58 EST by Ms Kate Rowe on behalf of School of Public Health