White matter microstructure in opiate addiction

Bora, Emre, Yucel, Murat, Fornito, Alex, Pantelis, Christos, Harrison, Ben J., Cocchi, Luca, Pell, Gaby and Lubman, Dan I. (2012) White matter microstructure in opiate addiction. Addiction Biology, 17 1: 141-148. doi:10.1111/j.1369-1600.2010.00266.x

Author Bora, Emre
Yucel, Murat
Fornito, Alex
Pantelis, Christos
Harrison, Ben J.
Cocchi, Luca
Pell, Gaby
Lubman, Dan I.
Title White matter microstructure in opiate addiction
Journal name Addiction Biology   Check publisher's open access policy
ISSN 1355-6215
Publication date 2012-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1111/j.1369-1600.2010.00266.x
Open Access Status Not yet assessed
Volume 17
Issue 1
Start page 141
End page 148
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Language eng
Subject 2701 Medicine (miscellaneous)
2738 Psychiatry and Mental health
3004 Pharmacology
Abstract Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially explains these findings is alterations in white matter connectivity secondary to chronic opiate use. However, few studies have quantitavely examined white matter deficits in opiate addiction (OA). Here, we investigated white matter microstructure in OA using diffusion tensor imaging (DTI). We performed voxel-wise analysis of fractional anisotropy (FA) in 24 participants with OA and 29 healthy controls. The OA group showed reduced FA in multiple pathways including the corpus callosum, thalamic radiation and inferior longitudinal fasciculus. This FA reduction was mainly the result of increased radial diffusivity (λ ⊥), indicative of myelin pathology. Longer duration of OA was also associated with axonal diffusivity (λ 1), most robustly in superior longitudinal fasciculi and right frontal white matter suggesting axonal injury in long-term users. Together, the findings indicate that chronic OA use has widespread and diverse effects on neuronal connectivity and function. © 2010 The Authors, Addiction Biology
Keyword Corpus callosum
White matter
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
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Created: Sat, 03 May 2014, 04:17:38 EST by Luca Cocchi on behalf of Queensland Brain Institute