The 'double pituitary hot spot' sign of skull base meningioma on gallium-68-labelled somatostatin analogue PET

Law, W.P., Fiumara, F., Fong, W. and MacFarlane, D.J. (2013) The 'double pituitary hot spot' sign of skull base meningioma on gallium-68-labelled somatostatin analogue PET. Journal of Medical Imaging and Radiation Oncology, 57 6: 680-683. doi:10.1111/1754-9485.12069

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Author Law, W.P.
Fiumara, F.
Fong, W.
MacFarlane, D.J.
Title The 'double pituitary hot spot' sign of skull base meningioma on gallium-68-labelled somatostatin analogue PET
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9477
1754-9485
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1111/1754-9485.12069
Open Access Status Not Open Access
Volume 57
Issue 6
Start page 680
End page 683
Total pages 4
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject 2741 Radiology Nuclear Medicine and imaging
2730 Oncology
Abstract Summary Gallium-68 (68Ga)-labelled somatostatin analogue imaging by positron emission tomography (PET) is increasingly replacing single photon (such as 111In-labelled octreotide) imaging in the detection and staging of carcinoid and other neuroendocrine tumours. Among other tissues, pituitary uptake of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-octreotate (DOTA-TATE) and other somatostatin analogues is physiological. DOTA-TATE also accumulates in meningiomas, which have a high density of somatostatin receptor expression. The combination of pituitary and skull base meningioma uptake results in a characteristic 'double hot spot' appearance, which indicates the presence of a meningioma. This is a case of a middle-aged woman who underwent 68Ga-DOTA-TATE PET for confirmation and staging of clinically suspected carcinoid tumour, in whom a skull base meningioma was incidentally discovered. With the increasing use of PET in the management of neuroendocrine tumours - and the not infrequent occurrence of meningiomas - the appearance of meningiomas on somatostatin analogue imaging should be one with which reporting clinicians are familiar.
Keyword gallium-68
meningioma
PET
somatostatin
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Wed, 30 Apr 2014, 09:00:58 EST by Matthew Lamb on behalf of School of Medicine