Sequence variations in the Boophilus microplus Bm86 locus and implications for immunoprotection in cattle vaccinated with this antigen

Garcia-Garcia, Jose C., Gonzalez, Ileana L., Gonzalez, Diana M., Valdes, Mario, Mendez, Luis, Lamberti, Jorge, D'Agostino, Beatriz, Citroni, Daniel, Fragoso, Hugo, Ortiz, Martin, Rodriguez, Manuel and De La Fuente, Jose (1999) Sequence variations in the Boophilus microplus Bm86 locus and implications for immunoprotection in cattle vaccinated with this antigen. Experimental and Applied Acarology, 23 11: 883-895. doi:10.1023/A:1006270615158


Author Garcia-Garcia, Jose C.
Gonzalez, Ileana L.
Gonzalez, Diana M.
Valdes, Mario
Mendez, Luis
Lamberti, Jorge
D'Agostino, Beatriz
Citroni, Daniel
Fragoso, Hugo
Ortiz, Martin
Rodriguez, Manuel
De La Fuente, Jose
Title Sequence variations in the Boophilus microplus Bm86 locus and implications for immunoprotection in cattle vaccinated with this antigen
Journal name Experimental and Applied Acarology   Check publisher's open access policy
ISSN 0168-8162
1572-9702
Publication date 1999-11-01
Year available 1999
Sub-type Article (original research)
DOI 10.1023/A:1006270615158
Volume 23
Issue 11
Start page 883
End page 895
Total pages 13
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Formatted abstract
Cattle tick infestations constitute a major problem for the cattle industry in tropical and subtropical regions of the world. Traditional control methods have been only partially successful, hampered by the selection of chemical-resistant tick populations. The Boophilus microplus Bm86 protein was isolated from tick gut epithelial cells and shown to induce a protective response against tick infestations in vaccinated cattle. Vaccine preparations including the recombinant Bm86 are used to control cattle tick infestations in the field as an alternative measure to reduce the losses produced by this ectoparasite. The principle for the immunological control of tick infestations relies on a polyclonal antibody response against the target antigen and, therefore, should be difficult to select for tick-resistant populations. However, sequence variations in the Bm86 locus, among other factors, could affect the effectiveness of Bm86-containing vaccines. In the present study we have addressed this issue, employing data obtained with B. microplus strains from Australia, Mexico, Cuba, Argentina and Venezuela. The results showed a tendency in the inverse correlation between the efficacy of the vaccination with Bm86 and the sequence variations in the Bm86 locus (R2 = 0.7). The mutation fixation index in the Bm86 locus was calculated and shown to be between 0.02 and 0.1 amino acids per year. Possible implications of these findings for the immunoprotection of cattle against tick infestations employing the Bm86 antigen are discussed.
Keyword Bm86
Cattle tick
Gavac
Diversity
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Alliance for Agriculture and Food Innovation
 
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Created: Tue, 29 Apr 2014, 15:07:10 EST by Dr Manuel Rodriguez Valle on behalf of Qld Alliance for Agriculture and Food Innovation