The role of transposable elements in health and diseases of the central nervous system

Reilly, Matthew T., Faulkner, Geoffrey J., Dubnau, Joshua, Ponomarev, Igor and Gage, Fred H. (2013) The role of transposable elements in health and diseases of the central nervous system. Journal of Neuroscience, 33 45: 17577-17586. doi:10.1523/JNEUROSCI.3369-13.2013

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Author Reilly, Matthew T.
Faulkner, Geoffrey J.
Dubnau, Joshua
Ponomarev, Igor
Gage, Fred H.
Title The role of transposable elements in health and diseases of the central nervous system
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
1529-2401
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.3369-13.2013
Open Access Status File (Publisher version)
Volume 33
Issue 45
Start page 17577
End page 17586
Total pages 10
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Abstract First discovered in maize by Barbara McClintock in the 1940s, transposable elements (TEs) areDNAsequences that in some cases have the ability to move along chromosomes or "transpose" in the genome. This revolutionary finding was initially met with resistance by the scientific community and viewed by some as heretical.Alarge body of knowledge has accumulated over the last 60 years on the biology of TEs. Indeed, it is now known that TEs can generate genomic instability and reconfigure gene expression networks both in the germline and somatic cells. This review highlights recent findings on the role of TEs in health and diseases of the CNS, which were presented at the 2013 Society for Neuroscience meeting. The work of the speakers in this symposium shows that TEs are expressed and active in the brain, challenging thedogmathat neuronal genomes are static and revealing that they are susceptible to somatic genomic alterations. Thesenew findings on TE expression and function in the CNS have major implications for understanding the neuroplasticity of the brain, which could hypothetically have a role in shaping individual behavior and contribute to vulnerability to disease.
Keyword Diagnostic certainty
Kappa index
Intraclass correlation coefficient
Lung disease
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID GNT1042449
R01NS067690
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2014 Collection
 
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Created: Mon, 28 Apr 2014, 23:14:59 EST by Dominique Rossouw on behalf of Mater Research Institute-UQ