Prophylactic antibiotics for inhibiting preterm labour with intact membrane

Flenady, Vicky, Hawley, Glenda, Stock, Owen M., Kenyon, Sara and Badawi, Nadia (2013) Prophylactic antibiotics for inhibiting preterm labour with intact membrane. Cochrane Database of Systematic Review, 12: CD000246.1-CD000246.118. doi:10.1002/14651858.CD000246.pub2

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Author Flenady, Vicky
Hawley, Glenda
Stock, Owen M.
Kenyon, Sara
Badawi, Nadia
Title Prophylactic antibiotics for inhibiting preterm labour with intact membrane
Journal name Cochrane Database of Systematic Review   Check publisher's open access policy
ISSN 1469-493X
Publication date 2013-12-05
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/14651858.CD000246.pub2
Open Access Status File (Publisher version)
Issue 12
Start page CD000246.1
End page CD000246.118
Total pages 118
Place of publication Oxford, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract Background
Formatted abstract
Background: The aetiology of preterm birth is complex and there is evidence that subclinical genital tract infection influences preterm labour in some women but the role of prophylactic antibiotic treatment in the management of preterm labour is controversial. Since rupture of the membranes is an important factor in the progression of preterm labour, it is important to see if the routine administration of antibiotics confers any benefit or causes harm, prior to membrane rupture.

Objectives: To assess the effects of prophylactic antibiotics administered to women in preterm labour with intact membranes, on maternal and neonatal outcomes.

Search methods: We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (31 August 2013).

Selection criteria: Randomised trials that compared antibiotic treatment with placebo or no treatment for women in preterm labour (between 20 and 36 weeks’ gestation) with intact membranes.

Data collection and analysis: Two review authors independently assessed trial eligibility, and undertook quality assessment and data extraction. We contacted study authors for additional information. Results are presented using risk ratio (RR) for categorical data and mean difference (MD) for data measured on a continuous scale with their respective 95% confidence intervals (CI). The number needed to treat to benefit (NNTB) and the number needed to treat to harm (NNTH) was calculated where appropriate
Keyword Medicine, General & Internal
General & Internal Medicine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2014 Collection
School of Public Health Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 41 times in Scopus Article | Citations
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Created: Fri, 25 Apr 2014, 00:06:26 EST by Dominique Rossouw on behalf of Mater Research Institute-UQ