Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography

Dayan, Michael, Munoz, Monica, Jentschke, Sebastian, Chadwick, Martin J., Cooper, Janine M., Riney, Kate, Vargha-Khadem, Faraneh and Clark, Chris A. (2013) Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography. Brain Structure and Function, Online First 1-16. doi:10.1007/s00429-013-0655-y

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Author Dayan, Michael
Munoz, Monica
Jentschke, Sebastian
Chadwick, Martin J.
Cooper, Janine M.
Riney, Kate
Vargha-Khadem, Faraneh
Clark, Chris A.
Title Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography
Journal name Brain Structure and Function   Check publisher's open access policy
ISSN 1863-2653
1863-2661
Publication date 2013-10-30
Sub-type Article (original research)
DOI 10.1007/s00429-013-0655-y
Open Access Status DOI
Volume Online First
Start page 1
End page 16
Total pages 16
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
The optic radiation (OR) is a component of the visual system known to be myelin mature very early in life. Diffusion tensor imaging (DTI) and its unique ability to reconstruct the OR in vivo were used to study structural maturation through analysis of DTI metrics in a cohort of 90 children aged 5–18 years. As the OR is at risk of damage during epilepsy surgery, we measured its position relative to characteristic anatomical landmarks. Anatomical distances, DTI metrics and volume of the OR were investigated for age, gender and hemisphere effects. We observed changes in DTI metrics with age comparable to known trajectories in other white matter tracts. Left lateralization of DTI metrics was observed that showed a gender effect in lateralization. Sexual dimorphism of DTI metrics in the right hemisphere was also found. With respect to OR dimensions, volume was shown to be right lateralised and sexual dimorphism demonstrated for the extent of the left OR. The anatomical results presented for the OR have potentially important applications for neurosurgical planning.
Keyword Probabilistic tractography
Diffusion imaging
DTI
Optic radiation
Maturation
Brain
Meyer's loop
Lateral geniculate nucleus
Epilepsy surgery
Neurosurgery planning
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online: 30 October 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Thu, 24 Apr 2014, 23:37:53 EST by Dominique Rossouw on behalf of School of Medicine