Oral and injectable synthetic progestagens effectively manipulate the estrous cycle in the Przewalski’s horse (Equus ferus przewalskii)

Collins, C. Wynne, Monfort, Steven L., Vick, Mandi M., Wolfe, Barbara A., Weiss, Rachel B., Keefer, Carol L. and Songsasen, Nucharin (2014) Oral and injectable synthetic progestagens effectively manipulate the estrous cycle in the Przewalski’s horse (Equus ferus przewalskii). Animal Reproduction Science, 148 1-2: 42-52. doi:10.1016/j.anireprosci.2014.03.018


Author Collins, C. Wynne
Monfort, Steven L.
Vick, Mandi M.
Wolfe, Barbara A.
Weiss, Rachel B.
Keefer, Carol L.
Songsasen, Nucharin
Title Oral and injectable synthetic progestagens effectively manipulate the estrous cycle in the Przewalski’s horse (Equus ferus przewalskii)
Formatted title
Oral and injectable synthetic progestagens effectively manipulate the estrous cycle in the Przewalski’s horse (Equus ferus przewalskii)
Journal name Animal Reproduction Science   Check publisher's open access policy
ISSN 0378-4320
1873-2232
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.anireprosci.2014.03.018
Volume 148
Issue 1-2
Start page 42
End page 52
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
To date, there has been limited research on manipulation of the estrous cycle in endangered equids. The objectives of this study were to assess the efficacy of using combinations of: (a) oral altrenogest and PGF2α, and (b) injectable altrenogest and PGF2α for manipulation of ovarian activity in Przewalski's mares. Reproductive cycles were monitored by assessing follicular changes with rectal ultrasound and changes in urinary steroid hormones. In Study 1, five cycling mares were treated with oral altrenogest (n = 11 cycles) for 14 days. In Study 2, cycling mares were treated with oral altrenogest for 12 days (n = 5 cycles; n = 5 mares) or a single injection of biorelease altrenogest (n = 10 cycles; n = 6 mares). In all study groups, PGF2α was given 2 days before cessation of progestagen treatment. In Study 1, mares responded in six of 11 cycles (54%) where treatment occurred with normal ovarian follicular development post hormone therapy. In Study 2, mares responded in four of five (80%, oral altrenogest) and eight of 10 (80%, injectable altrenogest) cycles with the development of an ovulatory follicle. With the use of injectable altrenogest, there was an obvious suppression of urinary estrogens and progetsagens. These results indicate that manipulation of the estrous cycle of Przewalski's mares can be achieved by administering oral (12 days) or injectable form of altrenogest in conjunction with PGF2α. Findings in the present study may have long term application for the development of timed artificial insemination as a genetic management tool for this critically endangered equid.
Keyword Estrous synchrony
Equids
Altrenogest
Ovulation induction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 8 April 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Veterinary Science Publications
 
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Created: Wed, 23 Apr 2014, 00:39:16 EST by Wynne Collins on behalf of School of Veterinary Science