Serum soluble CD23 but not IL8, IL10, GM-CSF, or IFN-γ is elevated in patients with hepatitis C infection

Bansal A.S., Bruce J., Hogan P.G., Prichard P. and Powell E.E. (1997) Serum soluble CD23 but not IL8, IL10, GM-CSF, or IFN-γ is elevated in patients with hepatitis C infection. Clinical Immunology and Immunopathology, 84 2: 139-144. doi:10.1006/clin.1997.4371


Author Bansal A.S.
Bruce J.
Hogan P.G.
Prichard P.
Powell E.E.
Title Serum soluble CD23 but not IL8, IL10, GM-CSF, or IFN-γ is elevated in patients with hepatitis C infection
Journal name Clinical Immunology and Immunopathology   Check publisher's open access policy
ISSN 0090-1229
Publication date 1997-01-01
Year available 1997
Sub-type Article (original research)
DOI 10.1006/clin.1997.4371
Open Access Status Not yet assessed
Volume 84
Issue 2
Start page 139
End page 144
Total pages 6
Place of publication SAN DIEGO
Publisher ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Language eng
Subject 2403 Immunology
2723 Immunology and Allergy
2734 Pathology and Forensic Medicine
Abstract The increased frequency of autoantibodies and B cell non-Hodgkins lymphoma (B-NHL) in hepatitis C virus (HCV) infection suggests dysregulated humoral immunity. Soluble CD23 (sCD23) is involved in B cell activation and proliferation and the serum levels are raised in autoimmune diseases and B cell lymphoproliferative disease. We compared the serum levels of sCD23 in patients with HCV infection with those in patients with alcoholic cirrhosis (AC) and in healthy controls. Serum levels of interleukin (IL) 8, IL10, granulocyte macrophage-colony stimulating factor, and interferon-gamma were assessed simultaneously to check for generalized nonspecific immune stimulation. In contrast to the essentially normal serum levels of these latter cytokines, the levels of sCD23 were raised in the patients with HCV compared to those with AC and the normal controls (medians 34.0, 10.1, and 11.1 arbitrary units, respectively; HCV vs AC P < 0.0004, HCV vs controls P < 0.0001, AC vs controls P > 0.8). These results confirm HCV-induced humoral immune dysregulation and invite comparison with primary Sjogrens syndrome and Epstein-Barr virus infection, both of which are also associated with raised levels of serum sCD23, autoantibodies, and B-NHL. (C) 1997 Academic Press.
Keyword Immunology
Pathology
Immunology
Pathology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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