Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression

Thompson, Sarah M., Hammen, Constance, Starr, Lisa R. and Najman, Jake M. (2014) Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression. Psychoneuroendocrinology, 43 11-19. doi:10.1016/j.psyneuen.2014.01.012

Author Thompson, Sarah M.
Hammen, Constance
Starr, Lisa R.
Najman, Jake M.
Title Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression
Journal name Psychoneuroendocrinology   Check publisher's open access policy
ISSN 0306-4530
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.psyneuen.2014.01.012
Open Access Status DOI
Volume 43
Start page 11
End page 19
Total pages 9
Place of publication Doetinchem, The Netherlands
Publisher Elsevier Ltd
Language eng
Subject 1310 Endocrinology
2712 Endocrinology, Diabetes and Metabolism
2738 Psychiatry and Mental health
2803 Biological Psychiatry
2807 Endocrine and Autonomic Systems
Abstract Maternal depression serves as a potent source of stress among offspring, greatly enhancing the risk of numerous adverse outcomes including youth depression. Several factors moderate the transmission of depression from mothers to offspring. However, the role of genetic characteristics in this process merits further exploration. Consistent with an interpersonal perspective on depression, the present study focused on a genetic polymorphism that has been shown to be relevant to social functioning, the rs53576 polymorphism of the oxytocin receptor gene (OXTR). In a community sample of 441 youth, OXTR genotype moderated the association between maternal depression in early childhood and youth depressive symptoms in adolescence, such that youth possessing at least one A allele of OXTR who also had a history of maternal depression exhibited the highest levels of depressive symptoms at age 15. In order to explore possible interpersonal mediators of this effect, conditional process analyses examined the role of youth social functioning in adolescence. Results suggest that OXTR genotype may partially account for the transmission of maternal depression to youth and support the role of dysfunctional social processes as a mechanism through which OXTR influences the development of depressive symptoms.
Keyword Adolescents
Intergenerational transmission of depression
Maternal depression
Oxytocin receptor gene
Social functioning
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01MH052239
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Social Science Publications
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