Concise review: next-generation cell therapies to prevent infections in neutropenic patients

Brunck, Marion E. G. and Nielsen, Lars K. (2014) Concise review: next-generation cell therapies to prevent infections in neutropenic patients. Stem Cells Translational Medicine, 3 4: 541-548. doi:10.5966/sctm.2013-0145

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Author Brunck, Marion E. G.
Nielsen, Lars K.
Title Concise review: next-generation cell therapies to prevent infections in neutropenic patients
Journal name Stem Cells Translational Medicine   Check publisher's open access policy
ISSN 2157-6580
2157-6564
Publication date 2014-04-01
Year available 2014
Sub-type Article (original research)
DOI 10.5966/sctm.2013-0145
Open Access Status Not Open Access
Volume 3
Issue 4
Start page 541
End page 548
Total pages 8
Place of publication Durham, NC, United States
Publisher AlphaMed Press
Language eng
Abstract High-dose chemotherapy is accompanied by an obligate period of neutropenia. Resulting bacterial and fungal infections are the leading cause of morbidity and mortality in neutropenic patients despite prophylactic antimicrobials and hematopoietic growth factor supplements. Replacing neutrophils in the patient through transfusion of donor cells is a logical solution to prevent fulminant infections. In the past, this strategy has been hampered by poor yield, inability to store collected cells, and possible donor morbidity caused by granulocyte colony-stimulating factor injections and apheresis. Today, neutrophil-like cells can be manufactured in the laboratory at the clinical scale from hematopoietic stem and progenitor cells enriched from umbilical cord blood. This article reviews the rationale for focusing research efforts toward ex vivo neutrophil production and explores clinical settings for future trials.
Keyword Cell therapy
Chemotherapy
Hematopoiesis
Neutropenia
Neutrophils
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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