Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women

Levinger, Itamar, Scott, David, Nicholson, Geoffrey C., Stuart, Amanda L., Duque, Gustavo, McCorquodale, Thomas, Herrmann, Markus, Ebeling, Peter R. and Sanders, Kerrie M. (2014) Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women. Bone, 64 8-12. doi:10.1016/j.bone.2014.03.008

Author Levinger, Itamar
Scott, David
Nicholson, Geoffrey C.
Stuart, Amanda L.
Duque, Gustavo
McCorquodale, Thomas
Herrmann, Markus
Ebeling, Peter R.
Sanders, Kerrie M.
Title Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women
Journal name Bone   Check publisher's open access policy
ISSN 8756-3282
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.bone.2014.03.008
Open Access Status Not yet assessed
Volume 64
Start page 8
End page 12
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 2712 Endocrinology, Diabetes and Metabolism
1314 Physiology
2722 Histology
Abstract We investigated the association between undercarboxylated osteocalcin (ucOC) and lower-limb muscle strength in women over the age of 70. years. The study also aims to confirm the association between bone turnover markers and heel ultrasound measures. A post-hoc analysis using data collected as part of a randomized placebo-controlled trial of vitamin D supplementation. An immunoassay was used to quantify total OC (tOC), with hydroxyapatite pre-treatment for ucOC. We determined associations of absolute and relative (ucOC/tOC; ucOC%) measures of ucOC with lower-limb muscle strength, heel ultrasound measures of speed of sound (SOS) and broadband ultrasound attenuation (BUA), bone turnover markers (BTMs; P1NP and CTx) and the acute phase protein alpha-1-antichymotrypsin (α-ACT). ucOC%, but not absolute ucOC concentration, was positively associated with hip flexor, hip abductor and quadriceps muscle strength (all p. <. 0.05). ucOC% was negatively associated with α-ACT (β-coefficient. =. -. 0.24, p. =. 0.02). tOC was positively associated with both P1NP and CTx (p. <. 0.001). For each per unit increase in tOC (μg/L) there was a corresponding lower BUA, SOS and SI (β-coefficient. =. -. 0.28; -. 0.23 and -. 0.23, respectively; all p. <. 0.04). In conclusion, ucOC% is positively associated with muscle strength and negatively associated with α-ACT. These data support a role for ucOC in musculoskeletal interactions in humans. Whilst tOC is associated with bone health, ucOC% and ucOC may also be linked to falls and fracture risk by influencing muscle function.
Keyword Bone remodelling
Muscle strength
Undercarboxylated osteocalcin
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 251682
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
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