A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network

Long, Haixia, Liu, Bing, Hou, Bing, Wang, Chao, Kendrick, Keith M., Yu, Chunshui and Jiang, Tianzi (2014) A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network. Chinese Science Bulletin, 59 13: 1355-1361. doi:10.1007/s11434-014-0185-x


Author Long, Haixia
Liu, Bing
Hou, Bing
Wang, Chao
Kendrick, Keith M.
Yu, Chunshui
Jiang, Tianzi
Title A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network
Journal name Chinese Science Bulletin   Check publisher's open access policy
ISSN 1861-9541
1001-6538
Publication date 2014-05-01
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s11434-014-0185-x
Open Access Status Not Open Access
Volume 59
Issue 13
Start page 1355
End page 1361
Total pages 7
Place of publication Beijing, China
Publisher Science in China Press
Language eng
Abstract The serotonin-transporter-linked polymorphic region (5-HTTLPR) is associated with mood disorders. This association is thought to be due to amygdala hyperresponsiveness to negative emotional stimuli as a result of reduced frontal cortical control. In Caucasians, the short form is associated with this effect, but in Han Chinese we recently found that the long form is involved. Serotonin receptors have rich expression in default mode network (DMN) regions and the recent studies have found an association between the short form of the 5-HTTLPR and DMN functional connectivity (FC) in Caucasians. The present study has investigated whether there may also be an ethnic difference in this influence of 5-HTTLPR on the DMN. We recruited 233 young Han Chinese subjects and calculated the resting-state default-network FC. Our study found that the L carriers had decreased FC in the bilateral medial prefrontal cortex, right parahippocampal gyrus, left middle temporal gyrus, and increased FC in left precuneus (Pcu) compared to SS. The PCC-Pcu FC in L carriers was significantly negatively correlated with the depression scores. Our findings, therefore, suggest that there is also a difference between Caucasian and Han Chinese subjects in the association between the different forms of the 5-HTTLPR and DMN functional connectivity.
Keyword 5-HTTLPR
Default mode network
Ethnic difference
Resting-state functional connectivity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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