openSNP-A crowdsourced web resource for personal genomics

Greshake, Bastian, Bayer, Philipp E., Rausch, Helge and Reda, Julia (2014) openSNP-A crowdsourced web resource for personal genomics. PLoS One, 9 3: e89204.1-e89204.9. doi:10.1371/journal.pone.0089204


Author Greshake, Bastian
Bayer, Philipp E.
Rausch, Helge
Reda, Julia
Title openSNP-A crowdsourced web resource for personal genomics
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-03-01
Sub-type Article (original research)
DOI 10.1371/journal.pone.0089204
Open Access Status DOI
Volume 9
Issue 3
Start page e89204.1
End page e89204.9
Total pages 9
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Abstract Genome-Wide Association Studies are widely used to correlate phenotypic traits with genetic variants. These studies usually compare the genetic variation between two groups to single out certain Single Nucleotide Polymorphisms (SNPs) that are linked to a phenotypic variation in one of the groups. However, it is necessary to have a large enough sample size to find statistically significant correlations. Direct-To-Consumer (DTC) genetic testing can supply additional data: DTC-companies offer the analysis of a large amount of SNPs for an individual at low cost without the need to consult a physician or geneticist. Over 100,000 people have already been genotyped through Direct-To-Consumer genetic testing companies. However, this data is not public for a variety of reasons and thus cannot be used in research. It seems reasonable to create a central open data repository for such data. Here we present the web platform openSNP, an open database which allows participants of Direct-To-Consumer genetic testing to publish their genetic data at no cost along with phenotypic information. Through this crowdsourced effort of collecting genetic and phenotypic information, openSNP has become a resource for a wide area of studies, including Genome-Wide Association Studies. openSNP is hosted at http://www.opensnp.org, and the code is released under MIT-license at http://github.com/gedankenstuecke/snpr.
Keyword Database
Cancer
Issues
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Agriculture and Food Sciences
Official 2015 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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