Irrational fixed dose combinations in Nepal: need for intervention

Poudel, A., Palaian, S., Shankar, P. R., Jayasekera, J. and Izham, M. I. M. (2008) Irrational fixed dose combinations in Nepal: need for intervention. Kathmandu University Medical Journal, 6 no.3 23: 399-405.


Author Poudel, A.
Palaian, S.
Shankar, P. R.
Jayasekera, J.
Izham, M. I. M.
Title Irrational fixed dose combinations in Nepal: need for intervention
Journal name Kathmandu University Medical Journal   Check publisher's open access policy
ISSN 1812-2078
1812-2027
Publication date 2008-01-01
Sub-type Critical review of research, literature review, critical commentary
Volume 6 no.3
Issue 23
Start page 399
End page 405
Total pages 7
Place of publication Kathmandu, Nepal
Publisher Kathmandu University * Kathmandu Medical College
Language eng
Abstract A large proportion of drugs available are of little importance in terms of fulfilling primary healthcare needs. Combination drugs increase the risk of side effects, lead to an ineffective dosage and liability to abuse and may also needlessly increase the cost. Drug combinations make it more difficult to find the causative agent responsible for the adverse reactions. In many cases their stability is doubtful, reducing the efficacy of many preparations. The Fifteenth WHO model list of essential medicines (March 2007) contains only 25 approved fixed dose combinations, whereas in Nepal, there are innumerable examples of irrational drug combinations, which are easily available and can be bought even without a prescription. A system of screening the drug combinations that are already licensed and available in the market is implemented in many developed and developing countries. Rational combinations can be of immense help to the health care system. These combinations may improve the quality of life for many and increase compliance. But irrational fixed dose combination products can be equally harmful.
Keyword Adverse drug reaction
Combination drugs
Fixed dose combination
Irrational drug use
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
 
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Created: Thu, 17 Apr 2014, 23:50:34 EST by Arjun Poudel on behalf of School of Pharmacy