Fibroblast proliferation alters cardiac excitation conduction and contraction: A computational study

Zhan, He-qing, Xia, Ling, Shou, Guo-fa, Zang, Yun-liang, Liu, Feng and Crozier, Stuart (2014) Fibroblast proliferation alters cardiac excitation conduction and contraction: A computational study. Journal of Zhejiang University: Science B, 15 3: 225-242. doi:10.1631/jzus.B1300156

Author Zhan, He-qing
Xia, Ling
Shou, Guo-fa
Zang, Yun-liang
Liu, Feng
Crozier, Stuart
Title Fibroblast proliferation alters cardiac excitation conduction and contraction: A computational study
Journal name Journal of Zhejiang University: Science B   Check publisher's open access policy
ISSN 1673-1581
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1631/jzus.B1300156
Open Access Status DOI
Volume 15
Issue 3
Start page 225
End page 242
Total pages 18
Place of publication Beijing, China
Publisher Zhejiang University Press
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
2700 Medicine
3000 Pharmacology, Toxicology and Pharmaceutics
3400 Veterinary
Abstract In this study, the effects of cardiac fibroblast proliferation on cardiac electric excitation conduction and mechanical contraction were investigated using a proposed integrated myocardial-fibroblastic electromechanical model. At the cellular level, models of the human ventricular myocyte and fibroblast were modified to incorporate a model of cardiac mechanical contraction and cooperativity mechanisms. Cellular electromechanical coupling was realized with a calcium buffer. At the tissue level, electrical excitation conduction was coupled to an elastic mechanics model in which the finite difference method (FDM) was used to solve electrical excitation equations, and the finite element method (FEM) was used to solve mechanics equations. The electromechanical properties of the proposed integrated model were investigated in one or two dimensions under normal and ischemic pathological conditions. Fibroblast proliferation slowed wave propagation, induced a conduction block, decreased strains in the fibroblast proliferous tissue, and increased dispersions in depolarization, repolarization, and action potential duration (APD). It also distorted the wave-front, leading to the initiation and maintenance of re-entry, and resulted in a sustained contraction in the proliferous areas. This study demonstrated the important role that fibroblast proliferation plays in modulating cardiac electromechanical behaviour and which should be considered in planning future heart-modeling studies.
Keyword Cardiac model
Fibroblast proliferation
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 61101046
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Information Technology and Electrical Engineering Publications
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