Targeting the nucleolus for cancer intervention

Quin, Jaclyn E., Devlin, Jennifer R., Cameron, Donald, Hannan, Kate M., Pearson, Richard B. and Hannan, Ross D. (2014) Targeting the nucleolus for cancer intervention. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1842 6: 802-816. doi:10.1016/j.bbadis.2013.12.009


Author Quin, Jaclyn E.
Devlin, Jennifer R.
Cameron, Donald
Hannan, Kate M.
Pearson, Richard B.
Hannan, Ross D.
Title Targeting the nucleolus for cancer intervention
Journal name Biochimica et Biophysica Acta - Molecular Basis of Disease   Check publisher's open access policy
ISSN 0925-4439
Publication date 2014-06-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbadis.2013.12.009
Open Access Status
Volume 1842
Issue 6
Start page 802
End page 816
Total pages 15
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 1312 Molecular Biology
1313 Molecular Medicine
Abstract The contribution of the nucleolus to cancer is well established with respect to its traditional role in facilitating ribosome biogenesis and proliferative capacity. More contemporary studies however, infer that nucleoli contribute a much broader role in malignant transformation. Specifically, extra-ribosomal functions of the nucleolus position it as a central integrator of cellular proliferation and stress signaling, and are emerging as important mechanisms for modulating how oncogenes and tumor suppressors operate in normal and malignant cells. The dependence of certain tumor cells to co-opt nucleolar processes to maintain their cancer phenotypes has now clearly been demonstrated by the application of small molecule inhibitors of RNA Polymerase I to block ribosomal DNA transcription and disrupt nucleolar function (Bywater et al., 2012 [1]). These drugs, which selectively kill tumor cells in vivo while sparing normal cells, have now progressed to clinical trials. It is likely that we have only just begun to scratch the surface of the potential of the nucleolus as a new target for cancer therapy, with "suppression of nucleolar stress" representing an emerging "hallmark" of cancer. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
Keyword Cancer
CX-5461
MYC
Nucleolar stress
P53
Ribosome biogenesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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