The arginine stimulation test: Timing of peak is not a helpful parameter in the diagnosis of growth hormone deficiency

Gillis, David, Granat, Nadav and Strich, David (2013) The arginine stimulation test: Timing of peak is not a helpful parameter in the diagnosis of growth hormone deficiency. Journal of Pediatric Endocrinology and Metabolism, 26 9-10: 813-817. doi:10.1515/jpem-2013-0075

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Author Gillis, David
Granat, Nadav
Strich, David
Title The arginine stimulation test: Timing of peak is not a helpful parameter in the diagnosis of growth hormone deficiency
Journal name Journal of Pediatric Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0334-018X
2191-0251
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1515/jpem-2013-0075
Open Access Status File (Publisher version)
Volume 26
Issue 9-10
Start page 813
End page 817
Total pages 5
Place of publication Berlin, Germany
Publisher Walter de Gruyter GmbH
Language eng
Formatted abstract
Background: A typical peak timing in the glucagon stimulation test has been reported as an indication of growth hormone (GH) deficiency. Other stimulation tests have not been evaluated.

Objective: To evaluate the clinical usefulness of peak timing in the arginine stimulation test (AST) for growth hormone deficiency.

Methods: Retrospective review of 199 ASTs from one center. Outcomes included correlation of peak times with (a) frequency of deficient peak; (b) growth velocity standard deviation scores (GVSDSs); (c) other evidence of pituitary pathology; (d) results of confirmatory clonidine test; and (e) response to GH treatment.

Results: The peak in 83/109 (76.14%) sufficient tests occurred at typical times vs. 45/72 (62.5%) deficient tests (p<0.05). GVSDS on GH treatment was greater among patients with typical timing in the AST compared with atypical timing (2.67±0.59 vs. 0.46±1.17, p=0.021). No other variable correlated significantly with AST timing.

Conclusions: Timing of peak in the AST is not a clinically useful parameter.
Keyword Arginine
Growth hormone deficiency
Short stature
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Fri, 11 Apr 2014, 01:41:07 EST by Matthew Lamb on behalf of School of Medicine