Bone mineral density in patients with nonalcoholic steatohepatitis among end-stage liver disease patients awaiting liver transplantation

Boonchaya-Anant, P., Hardy, E., Borg, B. B. and Burshell, A. L. (2013) Bone mineral density in patients with nonalcoholic steatohepatitis among end-stage liver disease patients awaiting liver transplantation. Endocrine Practice, 19 3: 414-419. doi:10.4158/EP12319.OR


Author Boonchaya-Anant, P.
Hardy, E.
Borg, B. B.
Burshell, A. L.
Title Bone mineral density in patients with nonalcoholic steatohepatitis among end-stage liver disease patients awaiting liver transplantation
Journal name Endocrine Practice   Check publisher's open access policy
ISSN 1530-891X
1934-2403
Publication date 2013-05-01
Sub-type Article (original research)
DOI 10.4158/EP12319.OR
Open Access Status Not Open Access
Volume 19
Issue 3
Start page 414
End page 419
Total pages 6
Place of publication Jacksonville, FL, United States
Publisher American Association of Clinical Endocrinologists
Language eng
Subject 1310 Endocrinology
2712 Endocrinology, Diabetes and Metabolism
Abstract Objective: Several studies have shown that patients with end-stage liver disease (ESLD) have lower bone mineral density (BMD) and a higher prevalence of osteoporosis compared to an age-matched population. Hyperinsulinemia and insulin resistance are typically associated with increased BMD. We hypothesized that patients with nonalcoholic steatohepatitis (NASH) and underlying insulin resistance may have higher BMD than patients with cirrhosis from other causes.Methods: We performed a retrospective chart review of patients with ESLD who underwent liver transplant evaluation at Ochsner Clinic Foundation and had a BMD study as part of initial work up and compared BMD values of patients diagnosed with NASH to patients with cirrhosis due to other causes. Patients were categorized into 3 groups based o. The etiology of their liver disease as NASH, alcoholic cirrhosis, or viral hepatitis C or B (HCV/HBV).Results: A total of 63 patients me. The study inclusion criteria, including 15 with NASH, 17 with alcoholic cirrhosis, and 31 with HCV/HBV. The overall prevalence rates of osteopenia and osteoporosis were 44% and 12%, respectively. BMD values were higher i. The NASH group tha. The HCV/HBV group at lumbar spine, total hip, and femoral neck (P = .01, .03, and .02, respectively). There were no statistical differences in BMD values between NASH and alcoholic cirrhosis groups at any site.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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Created: Wed, 09 Apr 2014, 01:59:40 EST by Matthew Lamb on behalf of School of Medicine