Health consequences of exposure to brominated flame retardants: a systematic review

Kim, Young Ran, Harden, Fiona A., Toms, Leisa-Maree L. and Norman, Rosana E. (2014) Health consequences of exposure to brominated flame retardants: a systematic review. Chemosphere, 106 1-19. doi:10.1016/j.chemosphere.2013.12.064


Author Kim, Young Ran
Harden, Fiona A.
Toms, Leisa-Maree L.
Norman, Rosana E.
Title Health consequences of exposure to brominated flame retardants: a systematic review
Journal name Chemosphere   Check publisher's open access policy
ISSN 1879-1298
0045-6535
ISBN 978-3-642-19268-5
Publication date 2014-01-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.chemosphere.2013.12.064
Open Access Status Not yet assessed
Volume 106
Start page 1
End page 19
Total pages 19
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Background: Brominated flame retardants (BFRs), are chemicals widely used in consumer products including electronics, vehicles, plastics and textiles to reduce flammability. Experimental animal studies have confirmed that these compounds may interfere with thyroid hormone homeostasis and neurodevelopment but to date health effects in humans have not been systematically examined.
Formatted abstract
Background: Brominated flame retardants (BFRs), are chemicals widely used in consumer products including electronics, vehicles, plastics and textiles to reduce flammability. Experimental animal studies have confirmed that these compounds may interfere with thyroid hormone homeostasis and neurodevelopment but to date health effects in humans have not been systematically examined.

Objectives: To conduct a systematic review of studies on the health impacts of exposure to BFRs in humans, with a particular focus on children.

Methods: A systematic review was conducted using the MEDLINE and EMBASE electronic databases up to 1 February 2012. Published cohort, cross-sectional, and case-control studies exploring the relationship between BFR exposure and various health outcomes were included.

Results: In total, 36 epidemiological studies meeting the pre-determined inclusion criteria were included. Plausible outcomes associated with BFR exposure include diabetes, neurobehavioral and developmental disorders, cancer, reproductive health effects and alteration in thyroid function. Evidence for a causal relationship between exposure to BFRs and health outcomes was evaluated within the Bradford Hill framework.

Conclusion: Although there is suggestive evidence that exposure to BFRs is harmful to health, further epidemiological investigations particularly among children, and long-term monitoring and surveillance of chemical impacts on humans are required to confirm these relationships.
Keyword Brominated flame retardants
Children
Exposure
Health
Human
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DE120100161
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
School of Public Health Publications
 
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