Selection for phase variation of los biosynthetic genes frequently occurs in progression of non-typeable haemophilus influenzae infection from the nasopharynx to the middle ear of human patients

Fox, Kate L., Atack, John M., Srikhanta, Yogitha N., Eckert, Anja, Novotny, Laura A., Bakaletz, Lauren O. and Jennings, Michael P. (2014) Selection for phase variation of los biosynthetic genes frequently occurs in progression of non-typeable haemophilus influenzae infection from the nasopharynx to the middle ear of human patients. PLoS One, 9 2: 1-6. doi:10.1371/journal.pone.0090505


Author Fox, Kate L.
Atack, John M.
Srikhanta, Yogitha N.
Eckert, Anja
Novotny, Laura A.
Bakaletz, Lauren O.
Jennings, Michael P.
Title Selection for phase variation of los biosynthetic genes frequently occurs in progression of non-typeable haemophilus influenzae infection from the nasopharynx to the middle ear of human patients
Formatted title
Selection for phase variation of los biosynthetic genes frequently occurs in progression of non-typeable haemophilus influenzae infection from the nasopharynx to the middle ear of human patients
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-02-28
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.pone.0090505
Open Access Status DOI
Volume 9
Issue 2
Start page 1
End page 6
Total pages 6
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Surface structures in Haemophilus influenzae are subject to rapid ON/OFF switching of expression, a process termed phase variation. We analyse tetranucleotide repeats controlling phase variation in lipo-oligosaccharide (LOS) genes of H. influenzae in paired isolates from both the nasopharynx and middle ears of paediatric patients with chronic or recurrent otitis media. A change in expression of at least one of the seven phase variable LOS biosynthesis genes was seen in 12 of the 21 strain pairs. Several strains showed switching of expression in multiple LOS genes, consistent with a key role for phase variable LOS biosynthetic genes in human infection.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Official Audit
School of Chemistry and Molecular Biosciences
 
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