Elevation of miR-221 and -222 in the internal mammary arteries of diabetic subjects and normalization with metformin

Coleman, C.B., Lightell, D.J., Moss, S.C., Bates, M., Parrino, P.E. and Woods, T.C. (2013) Elevation of miR-221 and -222 in the internal mammary arteries of diabetic subjects and normalization with metformin. Molecular and Cellular Endocrinology, 374 1-2: 125-129. doi:10.1016/j.mce.2013.04.019


Author Coleman, C.B.
Lightell, D.J.
Moss, S.C.
Bates, M.
Parrino, P.E.
Woods, T.C.
Title Elevation of miR-221 and -222 in the internal mammary arteries of diabetic subjects and normalization with metformin
Journal name Molecular and Cellular Endocrinology   Check publisher's open access policy
ISSN 0303-7207
1872-8057
Publication date 2013-07-05
Sub-type Article (original research)
DOI 10.1016/j.mce.2013.04.019
Volume 374
Issue 1-2
Start page 125
End page 129
Total pages 5
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Collection year 2014
Language eng
Subject 1310 Endocrinology
1312 Molecular Biology
1303 Specialist Studies in Education
Abstract Diabetes is a major risk factor for cardiovascular disease and is associated with increased intimal thickening and accelerated vascular smooth muscle cell (VSMC) proliferation. We measured the expression of two microRNAs that promote intimal thickening, miR-221/222, and mRNA encoding a downstream target, p27Kip1, in internal mammary artery (IMA) segments collected from 37 subjects undergoing coronary artery bypass grafting. The segments were stratified into three groups: non-diabetic subjects (ND), diabetic subjects not on metformin (DMMet-), and diabetic subjects on metformin (DMMet+). The DMMet- group exhibited a significant increase in miR-221/222 and decrease in p27Kip1 mRNA compared to both the ND and DMMet+ groups. miR-221/222 levels inversely correlated with metformin dose. VSMCs isolated from the IMAs of the DMMet- group proliferate at a faster rate than those of the ND and DMMet+ groups. Further studies into the importance of miR-221/222 in the increased intimal thickening observed in diabetic subjects is warranted.
Keyword Diabetes
Internal mammary artery
Metformin
MiR-221/222
Vascular smooth muscle cell
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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Created: Tue, 08 Apr 2014, 00:48:48 EST by Matthew Lamb on behalf of School of Medicine