Time to menarche and final height after histrelin implant treatment for central precocious puberty

Gillis, David, Karavani, Gilad, Hirsch, Harry J. and Strich, David (2013) Time to menarche and final height after histrelin implant treatment for central precocious puberty. Journal of Pediatrics, 163 2: 532-536. doi:10.1016/j.jpeds.2013.01.021


Author Gillis, David
Karavani, Gilad
Hirsch, Harry J.
Strich, David
Title Time to menarche and final height after histrelin implant treatment for central precocious puberty
Journal name Journal of Pediatrics   Check publisher's open access policy
ISSN 0022-3476
1097-6833
Publication date 2013-08-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jpeds.2013.01.021
Open Access Status
Volume 163
Issue 2
Start page 532
End page 536
Total pages 5
Place of publication Philadelphia, United States
Publisher Mosby
Language eng
Formatted abstract
Objective:
To compare final height, change in body mass index (BMI), and time from end of treatment until menarche in girls with central precocious puberty treated with the histrelin implant versus depot gonadotropin releasing hormone agonist injections.
Study design:
Chart review, interview, and final height measurements of 2 groups of girls with central precocious puberty; triptorelin depot (TD) group: 23 girls were treated from age 8.4 ± 0.3 with monthly injections of TD, for 26.7 ± 2.5 months; histrelin implant group: 11 girls were treated from age 8.7 ± 0.3 years for 28.4 ± 3.7 months, of whom 9 initially received monthly TD injections for 1.5-39 months. Final height, BMI (pretreatment vs recent), and time between either implant removal or last injection to menarche were compared.

Results:
Time between removal of implant or last injection and menarche was 9.3 ± 1.5 (histrelin implant group) versus 16.1 ± 1.7 (TD group) months (P =.02). Predicted height at implant insertion was 156.8 ± 2.6 cm, and final height was 161.1 ± 2.0 cm (not significant [NS]). Predicted height for TD was 155.2 ± 1.9 cm and final height was 157.9 ± 1.7 cm (NS). Change from onset of treatment to final BMI-SDS for histrelin implant was -0.41 ± 0.3, and for TD was -0.03 ± 0.2 (NS).

Conclusions:
Menarche occurred sooner after implant removal. There was no difference in final height or BMI outcomes between the 2 treatment modalities.
Keyword BMI
Body mass index
Central precocious puberty
CPP
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Mon, 07 Apr 2014, 20:14:50 EST by Matthew Lamb on behalf of School of Medicine