Isoprenylated proteins

McTaggart S.J. (2006) Isoprenylated proteins. Cellular and Molecular Life Sciences, 63 3: 255-267. doi:10.1007/s00018-005-5298-6


Author McTaggart S.J.
Title Isoprenylated proteins
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
Publication date 2006-01-01
Year available 2006
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00018-005-5298-6
Open Access Status
Volume 63
Issue 3
Start page 255
End page 267
Total pages 13
Place of publication BASEL
Publisher BIRKHAUSER VERLAG AG
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1307 Cell Biology
Abstract Isoprenoids are synthesized in all living organisms and are incorporated into diverse classes of end-products that participate in a multitude of cellular processes relating to cell growth, differentiation, cytoskeletal function and vesicle trafficking. In humans, the non-sterol isoprenoids, farnesyl pyrophosphate and geranylgeranyl-pyrophosphate, are synthesized via the mevalonate pathway and are covalently added to members of the small G protein superfamily. Isoprenylated proteins have key roles in membrane attachment and protein functionality, have been shown to have a central role in some cancers and are likely also to be involved in the pathogenesis and progression of atherosclerosis and Alzheimer disease. This review details current knowledge on the biosynthesis of isoprenoids, their incorporation into proteins by the process known as prenylation and the complex regulatory network that controls these proteins. An improved understanding of these processe is likely to lead to the development of novel therapies that will have important implications for human health and disease.
Keyword Isoprenylation
Mevalonate pathway
Statin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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