Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina

Venkataramani, Sowmya, Van Wyk, Michiel, Buldyrev, Ilya, Sivyer, Benjamin, Vaney, David I. and Taylor, W. Rowland (2014) Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina. Plos One, 9 2: e88560.1-e88560.10. doi:10.1371/journal.pone.0088560


Author Venkataramani, Sowmya
Van Wyk, Michiel
Buldyrev, Ilya
Sivyer, Benjamin
Vaney, David I.
Taylor, W. Rowland
Title Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina
Journal name Plos One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-02-21
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.pone.0088560
Open Access Status DOI
Volume 9
Issue 2
Start page e88560.1
End page e88560.10
Total pages 10
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Abstract This paper examines the role of inhibition in generating the receptive-field properties of local edge detector (LED) ganglion cells in the rabbit retina. We confirm that the feed-forward inhibition is largely glycinergic but, contrary to a recent report, our data demonstrate that the glycinergic inhibition contributes to temporal tuning for the OFF and ON inputs to the LEDs by delaying the onset of spiking; this delay was more pronounced for the ON inputs (~340 ms) than the OFF inputs (~12 ms). Blocking glycinergic transmission reduced the delay to spike onset and increased the responses to flickering stimuli at high frequencies. Analysis of the synaptic conductances indicates that glycinergic amacrine cells affect temporal tuning through both postsynaptic inhibition of the LEDs and presynaptic modulation of the bipolar cells that drive the LEDs. The results also confirm that presynaptic GABAergic transmission contributes significantly to the concentric surround antagonism in LEDs; however, unlike presumed LEDs in the mouse retina, the surround is only partly generated by spiking amacrine cells.
Keyword Cone bipolar cells
Ganglion-cells
Mammalian retina
Amacrine cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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