The less than whole breast radiotherapy approach

Lehman, Margot and Hickey, Brigid (2010) The less than whole breast radiotherapy approach. The Breast, 19 3: 180-187. doi:10.1016/j.breast.2010.03.005

Author Lehman, Margot
Hickey, Brigid
Title The less than whole breast radiotherapy approach
Journal name The Breast   Check publisher's open access policy
ISSN 0960-9776
Publication date 2010-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.breast.2010.03.005
Open Access Status
Volume 19
Issue 3
Start page 180
End page 187
Total pages 8
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Language eng
Abstract The addition of conventional whole breast irradiation (WBI) to breast conserving surgery (BCS) reduces the risk of early breast cancer recurrence and leads to a statistically and clinically significant improvement in overall survival. However, the long duration of conventional WBI regimens negatively impacts on quality of life. This has led investigators to evaluate an alternative approach of delivering radiation to a limited volume of tissue around the tumour cavity only (partial breast irradiation) and delivering a larger than standard dose of radiation with each treatment (accelerated partial breast irradiation, APBI). This approach may be achieved by a number of techniques: interstitial brachytherapy, intracavitary brachytherapy using the Mammosite device, intraoperative techniques using electrons or low-energy photons, external beam radiotherapy or permanent seed implant. This articles will review the rationale for the less that whole breast radiotherapy approach and describe the techniques by which it can be achieved and the results obtained to date. Finally, the 7 prospective randomised controlled trials of conventional WBI versus APBI which are open and currently recruiting patients will be discussed.
Keyword Partial breast irradiation
Accelerated partial breast irradiation
Interstitial brachytherapy
Intraoperative radiotherapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 04 Apr 2014, 19:40:38 EST by Brigid Hickey on behalf of Medicine - Mater Hospital