Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women

Verheus, Martijn, van Gils, Carla H., Kreijkamp-Kaspers, Sanne, Kok, Linda, Peeters, Petra H. M., Grobbee, Diederick E. and van Der Schouw, Yvonne T. (2008) Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women. Cancer Epidemiology Biomarkers and Prevention, 17 10: 2632-2638. doi:10.1158/1055-9965.EPI-08-0344


Author Verheus, Martijn
van Gils, Carla H.
Kreijkamp-Kaspers, Sanne
Kok, Linda
Peeters, Petra H. M.
Grobbee, Diederick E.
van Der Schouw, Yvonne T.
Title Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women
Journal name Cancer Epidemiology Biomarkers and Prevention   Check publisher's open access policy
ISSN 1055-9965
1538-7755
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1158/1055-9965.EPI-08-0344
Volume 17
Issue 10
Start page 2632
End page 2638
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher American Association for Cancer Research
Language eng
Formatted abstract
Background: The relatively high dietary intake of soy in Asian countries has been hypothesized to, at least partly, explain the lower breast cancer incidence patterns in these countries compared with the Western world. The aim of the present study was to determine the effect of daily soy supplementation on mammographic density, one of the strongest known risk factors for breast cancer.

Methods: A double-blind, randomized, controlled trial was conducted to compare the effects of soy protein intake containing 99 mg isoflavones daily with intake of milk protein (placebo) for the duration of 1 year. Two hundred and two Dutch postmenopausal women ages 60 to 75 years were randomized. Mammographic density was assessed using a quantitative computer-assisted method on digitized mammograms. Equol producer status was assessed in plasma provided at the final visit (soy group) or after a 3-day challenge with soy after the trial was finished (placebo group).

Results: A total of 175 women completed the baseline visits and at least one follow-up visit and were included in the intention-to-treat analyses. For 126 women, both pre- and post-trial mammograms were available. Mammographic density decreased in both study arms, but the decrease did not differ significantly between intervention and placebo groups. Equol producer status did not modify the results.

Conclusion: The results of this trial do not support the hypothesis that a diet high in soy protein among postmenopausal women decreases mammographic density.  
Keyword Oncology
Public, Environmental & Occupational Health
Oncology
Public, Environmental & Occupational Health
ONCOLOGY
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 2200.0048
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Discipline of General Practice Publications
 
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