Soy isoflavones, body composition, and physical performance

Kok L., Kreijkamp-Kaspers S., Grobbee D.E., Lampe J.W. and Van Der Schouw Y.T. (2005) Soy isoflavones, body composition, and physical performance. Maturitas, 52 2: 102-110. doi:10.1016/j.maturitas.2005.01.003

Author Kok L.
Kreijkamp-Kaspers S.
Grobbee D.E.
Lampe J.W.
Van Der Schouw Y.T.
Title Soy isoflavones, body composition, and physical performance
Journal name Maturitas   Check publisher's open access policy
ISSN 0378-5122
Publication date 2005-10-16
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.maturitas.2005.01.003
Volume 52
Issue 2
Start page 102
End page 110
Total pages 9
Language eng
Subject 1302 Curriculum and Pedagogy
2729 Obstetrics and Gynaecology
Abstract Objectives: Physiologic changes, occurring during the process of aging, can have serious health consequences, such as increased risk of chronic disease and disability. Decline in estradiol levels after menopause is hypothesized to contribute to this risk. Thus, hormone therapy (HT) might prevent or delay those changes. However, HT has serious side effects and alternative approaches are needed. Methods: We performed a 12-month double-blind randomized trial comparing soy protein containing 99 mg isoflavones (aglycone weights) with milk protein (placebo) daily in 202 postmenopausal women aged 60-75 years. Endpoints were body composition, and physical performance. Randomization resulted in reasonable well-balanced groups, 153 (76%) women completed the trial. Compliance was good (plasma genistein levels 55 ± 101 and 1259 ± 1610 nmol/L for placebo and soy group, respectively). The changes in the endpoints during the intervention period among the two intervention groups were analyzed. Results: Body mass index (BMI) and waist-to-hip ratio did not change during intervention. Handgrip strength at the final visit was slightly worse in the soy group compared to the placebo group (-0.45 kg (95% C.I.: -2.5, 1.6 kg; p = 0.7), but this difference was not statistically significant. Self-reported functional status, mobility and physical performance, all slightly improved during intervention but there were no differences between the groups. Conclusions: The results of the present trial do not support the view that soy isoflavones have favorable effects on body composition and physical performance in postmenopausal women.
Keyword BMI
Physical functioning
Postmenopausal women
Randomized trial
Soy isoflavones
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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