Fas ligand+ fallopian tube epithelium induces apoptosis in both Fas receptor+ T lymphocytes and endometrial cells

Illanes, Sebastian E., Maisey, Kevin, Sandoval, Marcelo, Reyes, Felipe E., Figueroa-Gaete, Claudio, Perez-Sepulveda, Alejandra, Busquets, Maritza, Gonzalez, Paticia and Imarai, Monica (2013) Fas ligand+ fallopian tube epithelium induces apoptosis in both Fas receptor+ T lymphocytes and endometrial cells. Fertility and Sterility, 100 2: 550-560. doi:10.1016/j.fertnstert.2013.04.013

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Author Illanes, Sebastian E.
Maisey, Kevin
Sandoval, Marcelo
Reyes, Felipe E.
Figueroa-Gaete, Claudio
Perez-Sepulveda, Alejandra
Busquets, Maritza
Gonzalez, Paticia
Imarai, Monica
Title Fas ligand+ fallopian tube epithelium induces apoptosis in both Fas receptor+ T lymphocytes and endometrial cells
Journal name Fertility and Sterility   Check publisher's open access policy
ISSN 0015-0282
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.fertnstert.2013.04.013
Volume 100
Issue 2
Start page 550
End page 560
Total pages 11
Place of publication Philadelphia, PA, United States
Publisher Elsevier Inc.
Language eng
Subject 2729 Obstetrics and Gynaecology
2743 Reproductive Medicine
Abstract Objective: To establish whether human fallopian tube (FT) epithelium can induce apoptosis in T lymphocytes and endometrial cells. Design: Laboratory-based study. Setting: Hospital. Patient(s): Women undergoing abdominal hysterectomy for FT samples, and women volunteers with and without endometriosis for endometrial biopsies. Intervention(s): FT samples obtained at time of surgery performed in reproductive-aged women with normal menstrual cycles. Main Outcome Measure(s): T lymphocytes or endometrial cells coincubated with FT epithelial cells and assayed for apoptosis by DNA nick-end labeling and caspase-3 activity, with the presence of Fas ligand (FasL) and Fas receptor (FasR) assessed by indirect immunostaining. Result(s): The epithelium of the FT-induced apoptosis in T cells as well as in human endometrial cells. The mechanism probably involves the FasL/FasR system; accordingly, we observed FasL at the apical surface of the epithelium and in the stroma of the FT at all phases of the menstrual cycle except during the early proliferative phase. The endometrial samples from patients with endometriosis did not express FasR and were resistant to apoptosis. Conclusion(s): In both FasR+ T lymphocytes and endometrial cells, FasL+ FT cells induce apoptosis. Data suggest that the FT epithelium acts as a barrier to limit the influx of lymphocytes as well as endometrial cells ascending the tube. Failure of these regulatory mechanisms may be related to the development of endometriosis. Copyright
Keyword Apoptosis
Endometrial cells
Fallopian epithelial cells
T lymphocytes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 02 Apr 2014, 23:09:17 EST by Roheen Gill on behalf of UQ Centre for Clinical Research