A genome-wide association scan (GWAS) for mean telomere length within the COGS project: Identified loci show little association with hormone-related cancer risk

Pooley, K.A., Bojesen, S.E., Weischer, M., Nielsen, S.F., Thompson, D., Amin Al Olama, A., Michailidou, K., Tyrer, J.P., Benlloch, S., Brown, J., Audley, T., Luben, R., Khaw, K.-T., Neal, D.E., Hamdy, F.C., Donovan, J.L., Kote-Jarai, Z., Baynes, C., Shah, M., Bolla, M.K., Wang, Q., Dennis, J., Dicks, E., Yang, R., Rudolph, A., Schildkraut, J., Chang-Claude, J., Burwinkel, B., Chenevix-Trench, G., Pharoah, P.D.P., Berchuck, A., Eeles, R.A., Easton, D.F., Dunning, A.M. and Nordestgaard, B.G. (2013) A genome-wide association scan (GWAS) for mean telomere length within the COGS project: Identified loci show little association with hormone-related cancer risk. Human Molecular Genetics, 22 24: 5056-5064. doi:10.1093/hmg/ddt355

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Author Pooley, K.A.
Bojesen, S.E.
Weischer, M.
Nielsen, S.F.
Thompson, D.
Amin Al Olama, A.
Michailidou, K.
Tyrer, J.P.
Benlloch, S.
Brown, J.
Audley, T.
Luben, R.
Khaw, K.-T.
Neal, D.E.
Hamdy, F.C.
Donovan, J.L.
Kote-Jarai, Z.
Baynes, C.
Shah, M.
Bolla, M.K.
Wang, Q.
Dennis, J.
Dicks, E.
Yang, R.
Rudolph, A.
Schildkraut, J.
Chang-Claude, J.
Burwinkel, B.
Chenevix-Trench, G.
Pharoah, P.D.P.
Berchuck, A.
Eeles, R.A.
Easton, D.F.
Dunning, A.M.
Nordestgaard, B.G.
Title A genome-wide association scan (GWAS) for mean telomere length within the COGS project: Identified loci show little association with hormone-related cancer risk
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 0964-6906
1460-2083
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.1093/hmg/ddt355
Volume 22
Issue 24
Start page 5056
End page 5064
Total pages 9
Place of publication Oxford, England, U.K.
Publisher Oxford University Press
Language eng
Subject 1311 Genetics
2716 Genetics (clinical)
1312 Molecular Biology
Abstract Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the "iCOGS" custom genotyping array. All ~200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend < 4 × 10-10) at 3p14.4 close to PXK and evidence (Ptrend < 7 × 10-7) for TL loci at 6p22.1 (ZNF311) and 20q11.2 (BCL2L1). We additionally confirmed (Ptrend < 5 × 10-14) the previously reported loci at 3q26.2 (TERC), 5p15.3 (TERT) and 10q24.3 (OBFC1) and found supportive evidence (Ptrend < 5 × 10-4) for the published loci at 2p16.2 (ACYP2), 4q32.2 (NAF1) and 20q13.3 (RTEL1). SNPs tagging these loci explain TL differences of up to 731 bp (corresponding to 18% of total TL in healthy individuals), however, they display little direct evidence for association with breast, ovarian or prostate cancer risks.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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Created: Tue, 01 Apr 2014, 23:24:45 EST by Matthew Lamb on behalf of School of Medicine