Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

Olalde, Inigo, Allentoft, Morten E., Sanchez-Quinto, Federico, Santpere, Gabriel, Chiang, Charleston W. K., DeGiorgio, Michael, Prado-Martinez, Javier, Rodriguez, Juan Antonio, Rasmussen, Simon, Quilez, Javier, Ramirez, Oscar, Marigorta, Urko M., Fernandez-Callejo, Marcos, Prada, Maria Encina, Encinas, Julio Manuel Vidal, Nielsen, Rasmus, Netea, Mihai G., Novembre, John, Sturm, Richard A., Sabeti, Pardis, Marques-Bonet, Tomas, Navarro, Arcadi, Willerslev, Eske and Lalueza-Fox, Carles (2014) Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature, 507 7491: 225-228. doi:10.1038/nature12960

Author Olalde, Inigo
Allentoft, Morten E.
Sanchez-Quinto, Federico
Santpere, Gabriel
Chiang, Charleston W. K.
DeGiorgio, Michael
Prado-Martinez, Javier
Rodriguez, Juan Antonio
Rasmussen, Simon
Quilez, Javier
Ramirez, Oscar
Marigorta, Urko M.
Fernandez-Callejo, Marcos
Prada, Maria Encina
Encinas, Julio Manuel Vidal
Nielsen, Rasmus
Netea, Mihai G.
Novembre, John
Sturm, Richard A.
Sabeti, Pardis
Marques-Bonet, Tomas
Navarro, Arcadi
Willerslev, Eske
Lalueza-Fox, Carles
Title Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1038/nature12960
Open Access Status DOI
Volume 507
Issue 7491
Start page 225
End page 228
Total pages 4
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet. However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Braña individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 260372
F32 GM106656
R01 HG007089
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
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