Profiling of immunoglobulins in resting and mechanically stimulated saliva

MacDonald, Michael, Ab Ghani, Nur Aziemah, Wan, Yunxia, Cooper-White, Justin, Dimeski, Goce and Punyadeera, Chamindie (2014) Profiling of immunoglobulins in resting and mechanically stimulated saliva. Bioanalysis, 6 5: 697-704. doi:10.4155/bio.14.21

Author MacDonald, Michael
Ab Ghani, Nur Aziemah
Wan, Yunxia
Cooper-White, Justin
Dimeski, Goce
Punyadeera, Chamindie
Title Profiling of immunoglobulins in resting and mechanically stimulated saliva
Journal name Bioanalysis   Check publisher's open access policy
ISSN 1757-6199
Publication date 2014-01-01
Sub-type Article (original research)
DOI 10.4155/bio.14.21
Volume 6
Issue 5
Start page 697
End page 704
Total pages 8
Place of publication London, United Kingdom
Publisher Future Science
Language eng
Formatted abstract
Background: Dysregulation of salivary immunoglobulins has been implicated in illnesses ranging from periodontal disease to HIV aids and malignant cancers. Despite these advances there is a lack of agreement among studies with regard to the salivary immunoglobulin levels in healthy controls.

Resting and mechanically stimulated saliva samples and matching serum samples were collected from healthy individuals (n = 33; 40-55 years of age; gender: 23 female, 10 male). A matrix-matched AlphaLISA® assay was developed to determine the concentrations of IgG1 and IgG4 in serum and saliva samples.

Clear relationships were observed in the flow rate and concentration of each immunoglobulin in the two types of saliva. This study affirms the need to establish and standardize collection methods before salivary IgGs are used for diagnostic purposes.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Tue, 01 Apr 2014, 11:16:57 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology