Disulfide-rich macrocyclic peptides as templates in drug design

Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014) Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 2: 248-257. doi:10.1016/j.ejmech.2014.03.011


Author Northfield, Susan E.
Wang, Conan K.
Schroeder, Christina I.
Durek, Thomas
Kan, Meng-Wei
Swedberg, Joakim E.
Craik, David J.
Title Disulfide-rich macrocyclic peptides as templates in drug design
Journal name European Journal of Medicinal Chemistry   Check publisher's open access policy
ISSN 1768-3254
0223-5234
Publication date 2014-04-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ejmech.2014.03.011
Volume 77
Issue 2
Start page 248
End page 257
Total pages 10
Place of publication Cedex, France
Publisher Elsevier
Language eng
Abstract Recently disulfide-rich head-to-tail cyclic peptides have attracted the interest of medicinal chemists owing to their exceptional thermal, chemical and enzymatic stability brought about by their constrained structures. Here we review current trends in the field of peptide-based pharmaceuticals and describe naturally occurring cyclic disulfide-rich peptide scaffolds, discussing their pharmaceutically attractive properties and benefits. We describe how we can utilise these stable frameworks to graft and/or engineer pharmaceutically interesting epitopes to increase their selectivity and bioactivity, opening up new possibilities for addressing ‘difficult’ pharmaceutical targets.
Keyword Disulfide bonds
Cyclic peptide
Cyclotide
Grafting
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 46 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 31 Mar 2014, 19:28:39 EST by Susan Allen on behalf of Institute for Molecular Bioscience