The role of DNA methylation in stress-related psychiatric disorders

Klengel, Torsten, Pape, Julius, Binder, Elisabeth B. and Mehta, Divya (2014) The role of DNA methylation in stress-related psychiatric disorders. Neuropharmacology, 80 115-132. doi:10.1016/j.neuropharm.2014.01.013

Author Klengel, Torsten
Pape, Julius
Binder, Elisabeth B.
Mehta, Divya
Title The role of DNA methylation in stress-related psychiatric disorders
Journal name Neuropharmacology   Check publisher's open access policy
ISSN 0028-3908
Publication date 2014-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neuropharm.2014.01.013
Open Access Status
Volume 80
Start page 115
End page 132
Total pages 18
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 3004 Pharmacology
2804 Cellular and Molecular Neuroscience
Abstract Epigenetic modifications in response to traumatic experience and stress are emerging as important factors in the long-term biological trajectories leading to stress-related psychiatric disorders, reflecting both environmental influences as well as individual genetic predisposition. In particular, recent evidence on DNA methylation changes within distinct genes and pathways but also on a genome-wide level provides new insights into the pathophysiology of stress related psychiatric disorders. This review summarizes current findings and concepts on DNA methylation changes in stress-related disorders with a focus on major depressive disorder and posttraumatic stress disorder (PTSD). We highlight studies of DNA methylation in animals and humans pertinent to these disorders, both focusing on candidate loci as well as genome-wide studies. We describe molecular mechanisms of how exposure to stress can induce long lasting changes in DNA methylation and how these may relate to the pathophysiology of depression and PTSD. We discuss data suggesting that DNA methylation, even in peripheral tissues, appears to be an informative reflection of environmental exposures on the genome and may have potential as a biomarker for the early prevention of stress-related disorders.
Keyword DNA methylation
Gene by environment interaction
Stress-related disorders
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes This article is part of a Special Issue entitled 'Neuroepigenetic disorders'

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 80 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 82 times in Scopus Article | Citations
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Created: Mon, 31 Mar 2014, 18:32:24 EST by Debra McMurtrie on behalf of Queensland Brain Institute