Prevalence, incidence and determinants of herpes simplex virus type 2 infection among HIV-Seronegative women at high-risk of HIV infection: a prospective study in Beira, Mozambique

Meque, Ivete, Dube, Karine, Feldblum, Paul J., Clements, Archie C. A., Zango, Arlinda, Cumbe, Fidelina, Chen, Pai Lien, Ferro, Josefo J. and van de Wijgert, Janneke H. (2014) Prevalence, incidence and determinants of herpes simplex virus type 2 infection among HIV-Seronegative women at high-risk of HIV infection: a prospective study in Beira, Mozambique. PLoS One, 9 2: e89705.1-e89705.10. doi:10.1371/journal.pone.0089705


Author Meque, Ivete
Dube, Karine
Feldblum, Paul J.
Clements, Archie C. A.
Zango, Arlinda
Cumbe, Fidelina
Chen, Pai Lien
Ferro, Josefo J.
van de Wijgert, Janneke H.
Title Prevalence, incidence and determinants of herpes simplex virus type 2 infection among HIV-Seronegative women at high-risk of HIV infection: a prospective study in Beira, Mozambique
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-02-01
Sub-type Article (original research)
DOI 10.1371/journal.pone.0089705
Open Access Status DOI
Volume 9
Issue 2
Start page e89705.1
End page e89705.10
Total pages 10
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Objectives: To estimate the prevalence, incidence and determinants of herpes simplex type 2 (HSV-2) infection, and associations between HSV-2 and incident HIV infection, among women at higher risk for HIV infection in Beira, Mozambique.

Methods: Between 2009 and 2012, 411 women aged 18–35 years at higher risk of HIV acquisition (defined as having had two or more sexual partners in the month prior to study enrollment) were enrolled and followed monthly for one year. At each study visit, they were counseled, interviewed, and tested for HSV-2 and HIV antibodies.

Results: The HSV-2 prevalence at baseline was 60.6% (95% CI: 55.7% –65.4%). Increasing age (aOR = 2.94, 95% CI: 1.74–4.97, P<0.001 and aOR = 3.39, 95% CI: 1.58–7.29, P = 0.002 for age groups of 21–24 and 25–35 years old respectively), lower educational level (aOR = 1.81, 95% CI: 1.09–3.02, P = 0.022), working full time (aOR = 8.56, 95% CI: 1.01–72.53, P = 0.049) and having practiced oral sex (aOR = 3.02, 95% CI: 1.16–7.89, P = 0.024) were strongly associated with prevalent HSV-2 infection. Thirty one participants seroconverted for HSV-2 (20.5%; 95% CI: 14.4% –27.9%) and 22 for HIV during the study period. The frequency of vaginal sex with a casual partner using a condom in the last 7 days was independently associated with incident HSV-2 infection (aOR = 1.91, 95% CI: 1.05–3.47, P = 0.034). Positive HSV-2 serology at baseline was not significantly associated with risk of subsequent HIV seroconversion.

Conclusions: Young women engaging in risky sexual behaviors in Beira had high prevalence and incidence of HSV-2 infection. Improved primary HSV-2 control strategies are urgently needed in Beira.
Keyword Human-Immunodeficiency-Virus
Hotel Workers
Tanzania
Antibodies
Bar
Epidemiology
Metaanalysis
Association
Acquisition
Population
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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