Subdiffraction-Limited Quantum Imaging within a Living Cell

Taylor, Michael A., Janousek, Jiri, Daria, Vincent, Knittel, Joachim, Hage, Boris, Bachor, Hans-A. and Bowen, Warwick P. (2014) Subdiffraction-Limited Quantum Imaging within a Living Cell. Physical Review X, 4 1: . doi:10.1103/PhysRevX.4.011017

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Author Taylor, Michael A.
Janousek, Jiri
Daria, Vincent
Knittel, Joachim
Hage, Boris
Bachor, Hans-A.
Bowen, Warwick P.
Title Subdiffraction-Limited Quantum Imaging within a Living Cell
Journal name Physical Review X   Check publisher's open access policy
ISSN 2160-3308
Publication date 2014-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1103/PhysRevX.4.011017
Open Access Status DOI
Volume 4
Issue 1
Total pages 7
Place of publication College Park, MD United States
Publisher American Physical Society
Language eng
Formatted abstract
We report both subdiffraction-limited quantum metrology and quantum-enhanced spatial resolution for the first time in a biological context. Nanoparticles are tracked with quantum-correlated light as they diffuse through an extended region of a living cell in a quantum-enhanced photonic-force microscope. This allows spatial structure within the cell to be mapped at length scales down to 10 nm. Control experiments in water show a 14% resolution enhancement compared to experiments with coherent light. Our results confirm the long-standing prediction that quantum-correlated light can enhance spatial resolution at the nanoscale and in biology. Combined with state-of-the-art quantum light sources, this technique provides a path towards an order of magnitude improvement in resolution over similar classical imaging techniques. 
Keyword Photonic Force Microscope
Dark field microscopy
Optical tweezers
Particle tracking
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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