Cellular location and major terminal networks of the orexinergic system in the brain of two megachiropterans

Dell, Leigh-Anne, Kruger, Jean-Leigh, Pettigrew, John D. and Manger, Paul R. (2013) Cellular location and major terminal networks of the orexinergic system in the brain of two megachiropterans. Journal of Chemical Neuroanatomy, 53 64-71. doi:10.1016/j.jchemneu.2013.09.001


Author Dell, Leigh-Anne
Kruger, Jean-Leigh
Pettigrew, John D.
Manger, Paul R.
Title Cellular location and major terminal networks of the orexinergic system in the brain of two megachiropterans
Journal name Journal of Chemical Neuroanatomy   Check publisher's open access policy
ISSN 0891-0618
1873-6300
Publication date 2013-11-01
Sub-type Article (original research)
DOI 10.1016/j.jchemneu.2013.09.001
Volume 53
Start page 64
End page 71
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Highlights
• The organization of orexinergic system is described in the brain of two species of megachiropteran bats.
• The system is organized in a similar manner to other mammals.
• There is a feature that reflects a phylogenetic signal in the evolution of this neural system.
• This difference in the orexinergic system appears to correlate with a diphyletic origin of the chiroptera.

The present study describes the distribution of orexin-A immunoreactive neurons and their terminal networks in the brains of two species of megachiropterans. In general the organization of the orexinergic system in the mammalian brain is conserved across species, but as one of two groups of mammals that fly and have a high metabolic rate, it was of interest to determine whether there were any specific differences in the organization of this system in the megachiropterans. Orexinergic neurons were limited in distribution to the hypothalamus, and formed three distinct clusters, or nuclei, a main cluster with a perifornical location, a zona incerta cluster in the dorsolateral hypothalamus and an optic tract cluster in the ventrolateral hypothalamus. The nuclear parcellation of the orexinergic system in the megachiropterans is similar to that seen in many mammals, but differs from the microchiropterans where the optic tract cluster is absent. The terminal networks of the orexinergic neurons in the megachiropterans was similar to that seen in a range of mammalian species, with significant terminal networks being found in the hypothalamus, cholinergic pedunculopontine and laterodorsal tegemental nuclei, the noradrenergic locus coeruleus complex, all serotonergic nuclei, the paraventricular nuclei of the epithalamus and adjacent to the habenular nuclei. While the megachiropteran orexinergic system is typically mammalian in form, it does differ from that reported for microchiropterans, and thus provides an additional neural character arguing for independent evolution of these two chiropteran suborders.
Keyword Megabat
Chiroptera
Neuromodulatory systems
Hypocretin
Orexin
Evolution
Mammalia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
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Created: Thu, 27 Mar 2014, 23:58:55 EST by Debra McMurtrie on behalf of Queensland Brain Institute