Microfluidic platforms for informed tissue scaffold development.

Chau, L. T., Frith, J. E., Mills, R. J., Menzies, D. J., Titmarsh, D. M. and Cooper-White, J. J. (2013). Microfluidic platforms for informed tissue scaffold development.. In Xiujun (James) Li and Yu Zhou (Ed.), Microfluidic Devices for Biomedical Applications (pp. 363-387) Sawston, Cambridge, UK: Woodhead Publishing. doi:10.1533/9780857097040

Author Chau, L. T.
Frith, J. E.
Mills, R. J.
Menzies, D. J.
Titmarsh, D. M.
Cooper-White, J. J.
Title of chapter Microfluidic platforms for informed tissue scaffold development.
Title of book Microfluidic Devices for Biomedical Applications
Place of Publication Sawston, Cambridge, UK
Publisher Woodhead Publishing
Publication Year 2013
Sub-type Chapter in textbook
DOI 10.1533/9780857097040
Series Woodhead Publishing Series in Biomaterials
ISBN 9780857096975
ISSN 2049-9485
Editor Xiujun (James) Li
Yu Zhou
Volume number 61
Chapter number 10
Start page 363
End page 387
Total pages 25
Total chapters 17
Language eng
Formatted Abstract/Summary
This chapter begins by outlining the key hurdles that currently exist in terms of achieving directed tissue genesis, in vitro and in vivo, from available mature, progenitor and stem cell sources. The chapter then proceeds to describe how microfluidic device platforms can provide the required insights to overcome these hurdles to clinical translation, including the optimization of soluble factor provision to enhance cell expansion and differentiation outcomes, the impacts of pore architecture and surface engineering on scaffold colonization, and the biophysical needs of cells when creating three dimensional artificial vascular pedicles for improved scaffold vascularization post-implantation.
Keyword Tissue engineering
Tissue genesis
Stem cells
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Wed, 26 Mar 2014, 22:22:12 EST by Dr Jessica Frith on behalf of Aust Institute for Bioengineering & Nanotechnology