Evaluation of a technique to measure heart rate variability in anaesthetised cats

Khor, Kuan Hua, Shiels, Ian A., Campbell, Fiona E., Greer, Ristan M., Rose, Annie and Mills, Paul C. (2014) Evaluation of a technique to measure heart rate variability in anaesthetised cats. Veterinary Journal, 199 2: 229-235. doi:10.1016/j.tvjl.2013.11.006


Author Khor, Kuan Hua
Shiels, Ian A.
Campbell, Fiona E.
Greer, Ristan M.
Rose, Annie
Mills, Paul C.
Title Evaluation of a technique to measure heart rate variability in anaesthetised cats
Journal name Veterinary Journal   Check publisher's open access policy
ISSN 1090-0233
1532-2971
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.tvjl.2013.11.006
Volume 199
Issue 2
Start page 229
End page 235
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Analysis of heart rate (HR) and heart rate variability (HRV) are powerful tools to investigate cardiac diseases, but current methods, including 24-h Holter monitoring, can be cumbersome and may be compromised by movement artefact. A commercially available data capture and analysis system was used in anaesthetised healthy cats to measure HR and HRV during pharmacological manipulation of HR. Seven healthy cats were subjected to a randomised crossover study design with a 7day washout period between two treatment groups, placebo and atenolol (1mg/kg, IV), with the efficacy of atenolol to inhibit β1 adrenoreceptors challenged by epinephrine. Statistical significance for the epinephrine challenge was set at P<0.0027 (Holm-Bonferroni correction), whereas a level of significance of P<0.05 was set for other variables.Analysis of the continuous electrocardiography (ECG) recordings showed that epinephrine challenge increased HR in the placebo group (P=0.0003) but not in the atenolol group. The change in HR was greater in the placebo group than in the atenolol group (P=0.0004). Therefore, compared to cats pre-treated with placebo, pre-treatment with atenolol significantly antagonised the tachycardia while not significantly affecting HRV. The increased HR in the placebo group following epinephrine challenge was consistent with a shift of the sympathovagal balance towards a predominantly sympathetic tone. However, the small (but not significant at the critical value) decrease in the normalised high-frequency component (HFnorm) in both groups of cats suggested that epinephrine induced a parasympathetic withdrawal in addition to sympathetic enhancement (increased normalised low frequency component or LFnorm). In conclusion, this model is a highly sensitive and repeatable model to investigate HRV in anaesthetised cats that would be useful in the laboratory setting for short-term investigation of cardiovascular disease and subtle responses to pharmacological agents in this species.
Keyword Autonomic nervous system
Cat
Electrocardiography
Heart rate
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 15 November 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Veterinary Science Publications
 
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