Transcranial direct current stimulation and simultaneous functional magnetic resonance imaging

Meinzer, Marcus, Lindenberg, Robert, Darkow, Robert, Ulm, Lena, Copland, David and Flöel, Agnes (2014) Transcranial direct current stimulation and simultaneous functional magnetic resonance imaging. Journal of Visualized Experiments, 1 86: e51730-e51730. doi:10.3791/51730

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Author Meinzer, Marcus
Lindenberg, Robert
Darkow, Robert
Ulm, Lena
Copland, David
Flöel, Agnes
Title Transcranial direct current stimulation and simultaneous functional magnetic resonance imaging
Journal name Journal of Visualized Experiments   Check publisher's open access policy
ISSN 1940-087X
Publication date 2014-04-27
Sub-type Article (original research)
DOI 10.3791/51730
Open Access Status Not yet assessed
Volume 1
Issue 86
Start page e51730
End page e51730
Total pages 1
Place of publication Somerville, MA, United States
Publisher Journal of Visualized Experiments
Language eng
Formatted abstract
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that uses weak electrical currents administered to the scalp to manipulate cortical excitability and, consequently, behavior and brain function. In the last decade, numerous studies have addressed short-term and long-term effects of tDCS on different measures of behavioral performance during motor and cognitive tasks, both in healthy individuals and in a number of different patient populations. So far, however, little is known about the neural underpinnings of tDCS-action in humans with regard to large-scale brain networks. This issue can be addressed by combining tDCS with functional brain imaging techniques like functional magnetic resonance imaging (fMRI) or electroencephalography (EEG).

In particular, fMRI is the most widely used brain imaging technique to investigate the neural mechanisms underlying cognition and motor functions. Application of tDCS during fMRI allows analysis of the neural mechanisms underlying behavioral tDCS effects with high spatial resolution across the entire brain. Recent studies using this technique identified stimulation induced changes in task-related functional brain activity at the stimulation site and also in more distant brain regions, which were associated with behavioral improvement. In addition, tDCS administered during resting-state fMRI allowed identification of widespread changes in whole brain functional connectivity.

Future studies using this combined protocol should yield new insights into the mechanisms of tDCS action in health and disease and new options for more targeted application of tDCS in research and clinical settings. The present manuscript describes this novel technique in a step-by-step fashion, with a focus on technical aspects of tDCS administered during fMRI.
Keyword Behavior
Issue 86
Noninvasive brain stimulation
Transcranial direct current stimulation (tDCS),
Anodal stimulation (atDCS)
Cathodal stimulation (ctDCS)
Neuromodulation
Task-related fMRI
Resting-state fMRI
Functional magnetic resonance imaging (fMRI)
Electroencephalography (EEG)
Inferior frontal gyrus (IFG)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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Created: Mon, 24 Mar 2014, 21:09:36 EST by Roheen Gill on behalf of UQ Centre for Clinical Research