Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control

Sullivan, Mitchell A., Aroney, Samuel T. N., Li, Shihan, Warren, Frederick J., Joo, Jin Suk, Mak, Ka Sin, Stapleton, David I., Bell-Anderson, Kim S. and Gilbert, Robert G. (2014) Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control. Biomacromolecules, 15 2: 660-665. doi:10.1021/bm401714v


Author Sullivan, Mitchell A.
Aroney, Samuel T. N.
Li, Shihan
Warren, Frederick J.
Joo, Jin Suk
Mak, Ka Sin
Stapleton, David I.
Bell-Anderson, Kim S.
Gilbert, Robert G.
Title Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1525-7797
1526-4602
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.1021/bm401714v
Open Access Status DOI
Volume 15
Issue 2
Start page 660
End page 665
Total pages 6
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Subject 1502 Bioengineering
2502 Biomaterials
2507 Polymers and Plastics
2505 Materials Chemistry
Abstract Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-liver glycogen over the diurnal cycle was characterized using size exclusion chromatography and transmission electron microscopy. Glycogen was found to be formed as smaller β particles, and then only assembled into large α particles, with a broad size distribution, significantly after the time when glycogen content had reached a maximum. This pathway, missing in diabetic animals, is likely to give optimal bloodglucose control during the daily feeding cycle. Lack of this control may contribute to, or result from, diabetes. This discovery suggests novel approaches to diabetes management.
Formatted abstract
Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-liver glycogen over the diurnal cycle was characterized using size exclusion chromatography and transmission electron microscopy. Glycogen was found to be formed as smaller β particles, and then only assembled into large α particles, with a broad size distribution, significantly after the time when glycogen content had reached a maximum. This pathway, missing in diabetic animals, is likely to give optimal blood-glucose control during the daily feeding cycle. Lack of this control may contribute to, or result from, diabetes. This discovery suggests novel approaches to diabetes management.
Keyword Liver-glycogen
Molecular-weight
Rat liver
Phosphorylase activities
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 28 December 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2014 Collection
 
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